Transphosphorylation Explained

Transphosphorylation is a chemical reaction in which a phosphate group or a phosphono group is transferred between a substrate and a receptor.[1] There are various phosphate esters in living body including nucleic acid, and phosphorylation reaction related to their synthesis and interconversion is the basis of biochemical reaction.[2] [3] In most cases, ATP is the substrate of the phosphate group as a substrate and the enzyme that catalyzes these reactions is referred to as kinase.[4]

Notes and References

  1. Ardecky . Robert J. . Bobkova . Ekaterina V. . Kiffer-Moreira . Tina . Brown . Brock . Ganji . Santhi . Zou . Jiwen . Pass . Ian . Narisawa . Sonoko . Iano . Flávia Godoy . Rosenstein . Craig . Cheltsov . Anton . Rascon . Justin . Hedrick . Michael . Gasior . Carlton . Forster . Anita . 2014-02-01 . Identification of a selective inhibitor of murine intestinal alkaline phosphatase (ML260) by concurrent ultra-high throughput screening against human and mouse isozymes . Bioorganic & Medicinal Chemistry Letters . 24 . 3 . 1000–1004 . 10.1016/j.bmcl.2013.12.043 . 1464-3405 . 3943210 . 24412070.
  2. Wang . Qian . Kang . Yoon-Suk . Alowaifeer . Abdullah . Shi . Kaixiang . Fan . Xia . Wang . Lu . Jetter . Jonathan . Bothner . Brian . Wang . Gejiao . McDermott . Timothy R. . 2018-05-25 . Phosphate starvation response controls genes required to synthesize the phosphate analog arsenate . Environmental Microbiology . 20 . 5 . 1782–1793 . 10.1111/1462-2920.14108 . 1462-2920 . 29575522. 4700039 .
  3. Tasnádi . Gábor . Zechner . Michaela . Hall . Mélanie . Baldenius . Kai . Ditrich . Klaus . Faber . Kurt . 2017-10-06 . Investigation of acid phosphatase variants for the synthesis of phosphate monoesters . Biotechnology and Bioengineering . 114 . 10 . 2187–2195 . 10.1002/bit.26352 . 1097-0290 . 28600898. 25563592 .
  4. Wan . Paul T. C. . Garnett . Mathew J. . Roe . S. Mark . Lee . Sharlene . Niculescu-Duvaz . Dan . Good . Valerie M. . Jones . C. Michael . Marshall . Christopher J. . Springer . Caroline J. . Barford . David . Marais . Richard . Cancer Genome Project . 2004-03-19 . Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF . Cell . 116 . 6 . 855–867 . 10.1016/s0092-8674(04)00215-6 . 0092-8674 . 15035987. free .

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