Transmembrane protein 44 explained

Transmembrane protein 44 is a protein that in humans is encoded by the TMEM44 gene.[1]

Gene

mRNA sequence of the TMEM44 gene is 1483 base pairs long, with 13 exons.[2]

Locus

TMEM44 gene is located at the end of the long arm of chromosome 3 in humans (Homo sapiens).[3]

Protein

TMEM44 is 428 amino acids in length. The molecular weight of the protein is 47.1kDa, and its formula is C2086H3315N585O611S22, with a total of 6619 atoms.[4] TMEM44 is predicted to be integrated in the plasma membrane of the endoplasmic reticulum.

Expression

There is an overall low level expression of TMEM44 protein throughout the developmental stages of an organism.[5]

Transcripts

There are 12 isoforms of TMEM44 including isoform a, isoform b, isoform c, isoform d, isoform X1, isoform X2, isoform X3, isoform X4, isoform X5, isoform X6, isoform X7, isoform X8.

Transmembrane Region Allocation

There are seven predicted transmembrane domains in TMEM44 protein.

Interacting Proteins

GSK3B (Glycogen synthase kinase 3 beta) is a protein predicted to physically interact with TMEM44.[6] [7] [8]

Post-Translational Modification

TMEM44 is predicted to undergo threonine, tyrosine and serine phosphorylations.[9]

Orthologs

TMEM44 orthologs includes groups such as amphibians, birds, fish, mammals.[10]

Paralogs

Predicted paralogous proteins of TMEM44 are C9IZ85, F8WCY1, F8WE47, H7C3X7, J3KQW3, Q6PL43, and Q96I73.[11]

Notes and References

  1. Web site: Entrez Gene: Transmembrane protein 44. 2018-05-01.
  2. Homo sapiens transmembrane protein 44, mRNA (cDNA clone IMAGE:4747146) - Nucleotide - NCBI. www.ncbi.nlm.nih.gov. 16 March 2005. 2018-02-18.
  3. Web site: TMEM44 transmembrane protein 44 [Homo sapiens (human)] - Gene - NCBI]. www.ncbi.nlm.nih.gov. 2018-02-15.
  4. Web site: ExPASy - ProtParam tool. web.expasy.org. en-US. 2018-04-22.
  5. Web site: EST Profile - Hs.478729. Group. Schuler. www.ncbi.nlm.nih.gov. 2018-04-23.
  6. Web site: IntAct Portal . IntAct. www.ebi.ac.uk. en. 2018-04-22.
  7. Web site: BioGRID Database of Protein, Chemical, and Genetic Interactions. Lab. Mike Tyers. thebiogrid.org. en. 2018-04-22.
  8. Web site: The Molecular INTeraction Database – An ELIXIR Core Resource. mint.bio.uniroma2.it. en-US. 2018-04-22.
  9. Web site: NetPhos 3.1 Server. www.cbs.dtu.dk. en. 2018-04-22.
  10. Web site: BLAST: Basic Local Alignment Search Tool. blast.ncbi.nlm.nih.gov. 2018-02-18.
  11. Web site: TMEM44 Gene - GeneCards TMM44 Protein TMM44 Antibody. Database. GeneCards Human Gene. www.genecards.org. 2018-04-23.

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