Transmembrane domain of ABC transporters explained

ABC transporter transmembrane domain is the main transmembrane structural unit of ATP-binding cassette transporter proteins, consisting of six alpha helixes that traverse the plasma membrane. Many members of the ABC transporter family have two such regions.[1] [2] [3] [4] [5] [6]

This family appears to correspond to ABC1 by TCDB classification.

Human proteins containing this domain

ABCB1

ABCB10; ABCB11; ABCB4; ABCB5; ABCB6; ABCB7; ABCB8;ABCB9
  • ABCC1; ABCC10; ABCC11; ABCC12; ABCC13; ABCC2; ABCC3;ABCC4
  • ABCC5; ABCC6; ABCC8; ABCC9; CFTR; TAP1
  • TAP2; TAPL;

    • Notes and References

    1. Kerr ID . Structure and association of ATP-binding cassette transporter nucleotide-binding domains . Biochim. Biophys. Acta . 1561 . 1 . 47–64 . 2002 . 11988180 . 10.1016/s0304-4157(01)00008-9. 7058003 . free .
    2. Hunt JF, Yuan YR, Martsinkevich O, Millen L, Thomas PJ, Karpowich N, Dai PL, MacVey K . Crystal structures of the MJ1267 ATP binding cassette reveal an induced-fit effect at the ATPase active site of an ABC transporter . Structure . 9 . 7 . 571–86 . 2001 . 11470432 . 10.1016/S0969-2126(01)00617-7. free .
    3. Hunt JF, Yuan YR, Blecker S, Martsinkevich O, Millen L, Thomas PJ . The crystal structure of the MJ0796ATP-binding cassette. Implications for the structural consequences of ATP hydrolysis in the active site of an ABC transporter . J. Biol. Chem. . 276 . 34 . 32313–21 . 2001 . 11402022 . 10.1074/jbc.M100758200. free .
    4. Kim SH, Hung LW, Wang IX, Nikaido K, Liu PQ, Ames GF . Crystal structure of the ATP-binding subunit of an ABC transporter . Nature . 396 . 6712 . 703–707 . 1998 . 9872322 . 10.1038/25393. 1998Natur.396..703H . 204996524 .
    5. Welte W, Breed J, Boos W, Diederichs K, Vonrhein C, Muller C, Diez J, Greller G, Schnell C . Crystal structure of MalK, the ATPase subunit of the trehalose/maltose ABC transporter of the archaeon Thermococcus litoralis . EMBO J. . 19 . 22 . 5951–61 . 2000 . 11080142 . 10.1093/emboj/19.22.5951 . 305842.
    6. Wiley DC, Gaudet R . Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing. EMBO J. . 20 . 17 . 4964–72 . 2001 . 11532960 . 10.1093/emboj/20.17.4964 . 125601.

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