Transformer (gene) explained
Transformer (gene) should not be confused with Transformer proteins.
| Transformer |
| Organism: | Drosophila melanogaster |
| Taxid: | 7227 |
| Symbol: | tra |
| Entrezgene: | 39849 |
| Refseqmrna: | NM_079390.3 |
| Refseqprotein: | NP_524114.1 |
| Uniprot: | P11596 |
| Chromosome: | 3L |
| Entrezchromosome: | NT_033778.4 |
| Genloc Start: | 16589909 |
| Genloc End: | 16591198 |
| Transformer 2 |
| Organism: | Drosophila melanogaster |
| Taxid: | 7227 |
| Symbol: | tra2 |
| Entrezgene: | 36619 |
| Refseqmrna: | NM_057416.3 |
| Refseqprotein: | NP_476764.1 |
| Uniprot: | P19018 |
| Chromosome: | 2R |
| Entrezchromosome: | NT_033778.4 |
| Genloc Start: | 14601653 |
| Genloc End: | 14604686 |
Transformer (tra) is a family of genes which regulate sex determination in insects such as flies.[1] [2] Among its effects, it regulates differences between males and females in Drosophila fruit flies.[3]
The tra-2 gene is needed for sexual differentiation in female fruit flies, and for spermatogenesis in the males. It is not in the same protein family as tra, but instead works together with it in the splicing enhancer complex.[4] [5]
Notes and References
- Verhulst EC, van de Zande L, Beukeboom LW . Insect sex determination: it all evolves around transformer . Current Opinion in Genetics & Development . 20 . 4 . 376–383 . August 2010 . 20570131 . 10.1016/j.gde.2010.05.001 . free . 205003182 . 11370/2174764d-bd1b-4e1f-b142-90aced0c3e55 .
- Web site: An X, Ota T, O'Neil MT, Steinmann-Zwicky M, Yamamoto D, et al.. Gene Review. tra - transformer. https://web.archive.org/web/20210805113400/https://www.wikigenes.org/e/gene/e/39849.html . 5 August 2021 . Nature Genetics. 7 December 2017.
- Rideout EJ, Narsaiya MS, Grewal SS . The Sex Determination Gene transformer Regulates Male-Female Differences in Drosophila Body Size . PLOS Genetics . 11 . 12 . e1005683 . December 2015 . 26710087 . 4692505 . 10.1371/journal.pgen.1005683 . free .
- Amrein H, Gorman M, Nöthiger R . The sex-determining gene tra-2 of Drosophila encodes a putative RNA binding protein . Cell . 55 . 6 . 1025–1035 . December 1988 . 3144434 . 10.1016/0092-8674(88)90247-4 . 21183373 .
- Web site: Transformer-2 sex-determining protein . UniProt . 7 December 2017 .
