Transcription factor II E explained
| general transcription factor IIE, polypeptide 1, alpha 56kDa |
| Hgncid: | 4650 |
| Symbol: | GTF2E1 |
| Altsymbols: | TF2E1 |
| Entrezgene: | 2960 |
| Omim: | 189962 |
| Refseq: | NM_005513 |
| Uniprot: | P29083 |
| Chromosome: | 3 |
| Arm: | q |
| Band: | 21 |
| Locussupplementarydata: | -q24 |
| general transcription factor IIE, polypeptide 2, beta 34kDa |
| Hgncid: | 4651 |
| Symbol: | GTF2E2 |
| Altsymbols: | TF2E2 |
| Entrezgene: | 2961 |
| Omim: | 189964 |
| Refseq: | NM_002095 |
| Uniprot: | P29084 |
| Chromosome: | 8 |
| Arm: | p |
| Band: | 12 |
Transcription factor II E (TFIIE) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex.[1] It is a tetramer of two alpha and two beta chains and interacts with TAF6/TAFII80, ATF7IP, and varicella-zoster virus IE63 protein.[2]
TFIIE recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.[2] Transcription factor II E is encoded by the GTF2E1 and GTF2E2 genes.[3] [4] [5] [6] TFIIE is thought to be involved in DNA melting at the promoter: it contains a zinc ribbon motif that can bind single stranded DNA.[7]
See also
Notes and References
- Book: Lewin, Benjamin . Genes VIII . limited . Pearson Prentice Hall . Upper Saddle River, NJ . 2004 . 636–637 . 0-13-144946-X .
- Web site: UniProtKB - P29083 (T2EA_HUMAN). UniProt. 2016-10-19.
- Ohkuma Y, Hashimoto S, Roeder RG, Horikoshi M . Identification of two large subdomains in TFIIE-alpha on the basis of homology between Xenopus and human sequences . Nucleic Acids Res. . 20 . 21 . 5838 . 1992 . 1454543 . 334425 . 10.1093/nar/20.21.5838.
- Heng HH, Xiao H, Shi XM, Greenblatt J, Tsui LC . Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome . Hum. Mol. Genet. . 3 . 1 . 61–4 . 1994 . 8162052 . 10.1093/hmg/3.1.61.
- Sumimoto H, Ohkuma Y, Sinn E, Kato H, Shimasaki S, Horikoshi M, Roeder RG . Conserved sequence motifs in the small subunit of human general transcription factor TFIIE . Nature . 354 . 6352 . 401–4 . 1991 . 1956404 . 10.1038/354401a0 . 1991Natur.354..401S . 4288495 .
- Ohkuma Y, Sumimoto H, Hoffmann A, Shimasaki S, Horikoshi M, Roeder RG . Structural motifs and potential sigma homologies in the large subunit of human general transcription factor TFIIE . Nature . 354 . 6352 . 398–401 . December 1991 . 1956403 . 10.1038/354398a0 . 4325438 .
- Lee TI, Young RA . Transcription of eukaryotic protein-coding genes . Annu. Rev. Genet. . 34 . 77–137 . 2000 . 11092823 . 10.1146/annurev.genet.34.1.77.
