Transcription factor DP explained

Symbol:DP
DP
Pfam:PF08781
Interpro:IPR014889
Prosite:PDOC00359
Merops:S9
Scop:1c5e
Cazy:GT1

In molecular biology, transcription factor DP (Dimerization Partner) is a family of proteins which function as transcription factors.DP forms a heterodimer with E2F and regulates genes involved in cell cycle progression. The transcriptional activity of E2F is inhibited by the retinoblastoma protein which binds to the E2F-DP heterodimer [1] and negatively regulates the G1-S transition.

See also

Notes and References

  1. Rubin SM, Gall AL, Zheng N, Pavletich NP . Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release . Cell . 123 . 6 . 1093–106 . December 2005 . 16360038 . 10.1016/j.cell.2005.09.044 . 6158027 . free .

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