Transcription factor II F explained

general transcription factor IIF, polypeptide 1, 74kDa
Hgncid:	4652
Symbol:	GTF2F1
Altsymbols:	TFIIF, BTF4, RAP74
Entrezgene:	2962
Omim:	189968
Refseq:	NM_002096
Uniprot:	P35269
Chromosome:	19
Arm:	p
Band:	13.3

general transcription factor IIF, polypeptide 2, 30kDa
Hgncid:	4653
Symbol:	GTF2F2
Altsymbols:	TFIIF, BTF4, RAP30
Entrezgene:	2963
Omim:	189969
Refseq:	NM_004128
Uniprot:	P13984
Chromosome:	13
Arm:	q
Band:	14

general transcription factor IIF, polypeptide 2-like
Hgncid:	4654
Symbol:	GTF2F2L
Altsymbols:	TFIIF
Entrezgene:	2964
Refseq:	NG_003013
Chromosome:	4
Arm:	q
Band:	31.22

Transcription factor II F (TF_IIF) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex.^{[1] [2] [3]}

TF_IIF is encoded by the,, and genes.^{[4] [5] [6]}

TF_IIF binds to RNA polymerase II when the enzyme is already unbound to any other transcription factor, thus preventing it from contacting DNA outside the promoter. Furthermore, TF_IIF stabilizes the RNA polymerase II while it's contacting TBP and TF_IIB.

See also

• TF_IIA
• TF_IIB
• TF_IID
• TF_IIE
• TF_IIH

Notes and References

1. Book: Lewin, Benjamin . Genes VIII . Pearson Prentice Hall . Upper Saddle River, NJ . 2004 . 636–637 . 0-13-144946-X .
2. Lee TI, Young RA . Transcription of eukaryotic protein-coding genes . Annu. Rev. Genet. . 34 . 77–137 . 2000 . 11092823 . 10.1146/annurev.genet.34.1.77.
3. Kim TK, Lagrange T, Wang YH, Griffith JD, Reinberg D, Ebright RH. Richard H. Ebright. 1997. Trajectory of DNA in the RNA polymerase II transcription preinitiation complex. Proc Natl Acad Sci USA. 94. 23. 12268–73. 9356438. 10.1073/pnas.94.23.12268. 24903. 1997PNAS...9412268K. free.
4. Finkelstein A, Kostrub CF, Li J, Chavez DP, Wang BQ, Fang SM, Greenblatt J, Burton ZF . A cDNA encoding RAP74, a general initiation factor for transcription by RNA polymerase II . Nature . 355 . 6359 . 464–7 . 1992 . 1734284 . 10.1038/355464a0 . 1992Natur.355..464F . 1241044 .
5. Heng HH, Xiao H, Shi XM, Greenblatt J, Tsui LC . Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome . Hum. Mol. Genet. . 3 . 1 . 61–4 . 1994 . 8162052 . 10.1093/hmg/3.1.61 .
6. Purrello M, Di Pietro C, Rapisarda A, Mirabile E, Motta S, Sichel G, Grzeschik KH . Genetic characterization of general transcription factors TFIIF and TFIIB of Homo sapiens sapiens . Cytogenet. Cell Genet. . 69 . 1–2 . 75–80 . 1995 . 7835093 . 10.1159/000133942 .