Trans-feruloyl-CoA hydratase explained

trans-feruloyl-CoA hydratase
Ec Number:	4.2.1.101
Cas Number:	197462-62-7
Go Code:	0050548

In enzymology, a trans-feruloyl-CoA hydratase is an enzyme that catalyzes the chemical reaction

4-hydroxy-3-methoxyphenyl-beta-hydroxypropanoyl-CoA

\rightleftharpoons trans-feruloyl-CoA + H₂O

Hence, this enzyme has one substrate, 4-hydroxy-3-methoxyphenyl-beta-hydroxypropanoyl-CoA, and two products, trans-feruloyl-CoA and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 4-hydroxy-3-methoxyphenyl-beta-hydroxypropanoyl-CoA hydro-lyase (trans-feruloyl-CoA-forming). This enzyme is also called trans-feruloyl-CoA hydro-lyase (incorrect).

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .

References

• Narbad A, Gasson MJ . Metabolism of ferulic acid via vanillin using a novel CoA-dependent pathway in a newly-isolated strain of Pseudomonas fluorescens . Microbiology . 1998. 144 . 1397 - 405 . 9611814 . 10.1099/00221287-144-5-1397 . 5 . free .
• ((Pometto AL III)), Crawford DL . 1983 . Whole-cell bioconversion of vanillin to vanillic acid by Streptomyces viridosporus . Appl. Environ. Microbiol. . 45 . 1582 - 5 . 6870241 . 5 . 10.1128/AEM.45.5.1582-1585.1983 . 242504 . 1983ApEnM..45.1582P .