Tozorakimab Explained

Drug Name:	Tozorakimab
Synonyms:	MEDI 3506
Type:	mab
Target:	Interleukin 33
Cas Number:	2376858-66-9
Unii:	OHZ2MEL7FD

Tozorakimab (formerly MEDI 3506) is a monoclonal antibody against interleukin-33 (IL-33) that works via RAGE and epidermal growth factor receptors.^{[1] [2] [3] [4]}

Notes and References

1. Wilkinson . Tom . De Soyza . Anthony . Carroll . Miles . Chalmers . James D. . Crooks . Michael G. . Griffiths . Gareth . Shankar-Hari . Manu . Ho . Ling-Pei . Horsley . Alex . Kell . Chris . Lara . Beatriz . Mishra . Biswa . Moate . Rachel . Page . Clive . Pandya . Hitesh . Raw . Jason . Reid . Fred . Saralaya . Dinesh . Scott . Ian C. . Siddiqui . Salman . Ustianowski . Andy . van Zuydam . Natalie . Woodcock . Ashley . Singh . Dave . A randomised phase 2a study to investigate the effects of blocking interleukin-33 with tozorakimab in patients hospitalised with COVID-19: ACCORD-2 . ERJ Open Research . September 2023 . 9 . 5 . 00249–2023 . 10.1183/23120541.00249-2023. 37868151 . 10588785 .
2. Cazzola . M. . Rogliani . P. . Calzetta . L. . Matera . M.G. . Tozorakimab. Anti-IL-33 monoclonal antibody, Treatment of COPD and asthma, Treatment of atopic dermatitis, Treatment of diabetic kidney disease . Drugs of the Future . 2023 . 48 . 2 . 101 . 10.1358/dof.2023.48.2.3474010. 256560283 .
3. Book: Scott . I C . England . E . Rees . D G . Erngren . T . Chaillan Huntington . C . Houslay . K F . Sims . D A . Hollins . C . Hinchy . E C . Colley . C . Corkill . D J . Cohen . E S . 05.01 - Airway pharmacology and treatment . Tozorakimab: a dual-pharmacology anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction . 4 September 2022 . 2467 . 10.1183/13993003.congress-2022.2467.
4. England . Elizabeth . Rees . D. Gareth . Scott . Ian Christopher . Carmen . Sara . Chan . Denice T. Y. . Chaillan Huntington . Catherine E. . Houslay . Kirsty F. . Erngren . Teodor . Penney . Mark . Majithiya . Jayesh B. . Rapley . Laura . Sims . Dorothy A. . Hollins . Claire . Hinchy . Elizabeth C. . Strain . Martin D. . Kemp . Benjamin P. . Corkill . Dominic J. . May . Richard D. . Vousden . Katherine A. . Butler . Robin J. . Mustelin . Tomas . Vaughan . Tristan J. . Lowe . David C. . Colley . Caroline . Cohen . E. Suzanne . Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction . Scientific Reports . 17 June 2023 . 13 . 1 . 9825 . 10.1038/s41598-023-36642-y . 37330528 . 10276851 . 2023NatSR..13.9825E . en . 2045-2322.