Toxoplasma lactate dehydrogenase 1 regulatory UTR explained

LDH1 5′UTR
Rfam:	RF02697
Tax Domain:	Bacteria
So:	,

In Toxoplasma gondii the translational repression of lactate dehydrogenase 1 (LDH1) was discovered to be mediated through its 5′UTR. A small nucleotide regulatory RNA hairpin was shown to be essential for the repression. It is possible that this hairpin may act as the nucleation site for the binding of a trans-acting factor(s) that allow for the translational repression.^[1]

Notes and References

1. Holmes M, Itaas V, Ananvoranich S . Sustained translational repression of lactate dehydrogenase 1 in Toxoplasma gondii bradyzoites is conferred by a small regulatory RNA hairpin . The FEBS Journal . 281 . 22 . 5077–5091 . November 2014 . 25223457 . 10.1111/febs.13048 . 45643970 . free .