| Touffailles | |
| Commune Status: | Commune |
| Image Coat Of Arms: | Blason ville fr Touffailles (Tarn-et-Garonne).svg |
| Arrondissement: | Castelsarrasin |
| Canton: | Pays de Serres Sud-Quercy |
| Insee: | 82182 |
| Postal Code: | 82190 |
| Mayor: | Jean-Michel Barreau[1] |
| Term: | 2020 - 2026 |
| Coordinates: | 44.2739°N 1.0514°W |
| Elevation M: | 220 |
| Elevation Min M: | 118 |
| Elevation Max M: | 276 |
| Area Km2: | 24.34 |
Touffailles (in French pronounced as /tufaj/; Occitan (post 1500);: Tofalhas) is a commune in the Tarn-et-Garonne department in the Occitanie region in southern France.
The Séoune forms parts of the commune's south-eastern border.