Tosagestin Explained

Tosagestin (developmental code name ORG-30659), also known as 11-methylene-δ15-norethisterone or 17α-ethynyl-11-methylene-19-nor-δ15-testosterone, is a progestin of the 19-nortestosterone group which was under development by Organon in the United States and Europe as a hormonal contraceptive (in combination with ethinylestradiol) and for the treatment of menopausal symptoms but was never marketed.[1] [2] [3]

See also

Notes and References

  1. Verhoeven CH, Krebbers SF, Wagenaars GN, Booy CJ, Groothuis GM, Olinga P, Vos RM . In vitro and in vivo metabolism of the progestagen Org 30659 in several species . Drug Metabolism and Disposition . 26 . 11 . 1102–1112 . November 1998 . 9806953 .
  2. de Visser SJ, Uchida N, van Vliet-Daskalopoulou E, Fukazawa I, van Doorn MB, van den Heuvel MW, Machielsen CS, Uchida E, Cohen AF . 6 . Pharmacokinetic differences between Caucasian and Japanese subjects after single and multiple doses of a potential combined oral contraceptive (Org 30659 and EE) . Contraception . 68 . 3 . 195–202 . September 2003 . 14561540 . 10.1016/S0010-7824(03)00140-9 .
  3. Obruca A, Korver T, Huber J, Killick SR, Landgren B, Struijs MJ . Ovarian function during and after treatment with the new progestagen Org 30659 . Fertility and Sterility . 76 . 1 . 108–115 . July 2001 . 11438328 . 10.1016/S0015-0282(01)01824-6 . free .

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