| Pushpin Label Position: | left |
| Coordinates: | 40.2667°N 38°W |
| Province: | (LE) |
| Frazioni: | Borgagne, Roca Vecchia, San Foca, Torre dell'Orso, Torre Sant'Andrea, Torre SaracenaTorre Specchia |
| Mayor: | Marco Potì |
| Area Total Km2: | 92.31 |
| Population Footnotes: | [1] |
| Population Total: | 10034 |
| Population As Of: | 31-8-2022 |
| Population Demonym: | Melendugnesi |
| Elevation M: | 36 |
| Saint: | St. Nicetas the Goth |
| Day: | Second Sunday in September |
| Postal Code: | 73026 |
| Area Code: | 0832 |
240px|thumb|D'Amely baronial Palace.Melendugno (Salentino: Sicilian: Melendugnu or Sicilian: Malandugnu) is a town and comune in the province of Lecce in the Apulia region of south-east Italy.
It is known for its marine, which are bathing beaches on the Adriatic Sea: Roca Vecchia, San Foca, Torre dell'Orso and Torre Sant'Andrea, which were awarded the Blue Flag beach prize for the water quality. Melendugno also includes the of Borgagne.