Topisaw Creek is a stream in the U.S. state of Mississippi. It is a tributary to Bogue Chitto.
Topisaw is a name derived from the Choctaw language purported to mean "little chestnut".[1] Variant names are "East Topisaw Creek", "Otapasso Creek", "Otuspasso Brook", "Topisaw River", and "Topsaw River".