Tomaymycin Explained

Tomaymycin is an antitumor and antibiotic pyrrolobenzodiazepine with the molecular formula C₁₆H₂₀N₂O₄.^{[1] [2]} Tomaymycin is produced by the bacterium Streptomyces achromogenes.^[3]

Further reading

• Book: Szeinbach . Sheryl Lynn . The Genetic Activity of Anthramycin, Tomaymycin and Sibiromycin in Bacterial Forward- and Reverse-mutation Assays and in the Mouse Bone-marrow Micronucleus Test . 1983 . University of Kentucky . en.
• Book: Corcoran . John W. . Biosynthesis . 6 December 2012 . Springer Science & Business Media . 978-3-642-67724-3 . 290 . en.
• Benedetti . Françoise . Perrin . Marc-Antoine . Bosc . Sebastien . Chouteau . Franck . Champion . Nicolas . Bigot . Antony . Total Synthesis of (+)-Oxo-tomaymycin . Organic Process Research & Development . 15 May 2020 . 24 . 5 . 762–768 . 10.1021/acs.oprd.0c00009. 213969939 .

Notes and References

1. von Tesmar . Alexander . Hoffmann . Michael . Pippel . Jan . Fayad . Antoine Abou . Dausend-Werner . Stefan . Bauer . Armin . Blankenfeldt . Wulf . Müller . Rolf . Total Biosynthesis of the Pyrrolo[4,2]benzodiazepine Scaffold Tomaymycin on an In Vitro Reconstituted NRPS System . Cell Chemical Biology . October 2017 . 24 . 10 . 1216–1227.e8 . 10.1016/j.chembiol.2017.08.001. 28890318 . free .
2. Tomaymycin Antitumor Antibiotic MedChemExpress . MedchemExpress.com .
3. Li . Wei . Chou . ShenChieh . Khullar . Ankush . Gerratana . Barbara . Cloning and Characterization of the Biosynthetic Gene Cluster for Tomaymycin, an SJG-136 Monomeric Analog . Applied and Environmental Microbiology . May 2009 . 75 . 9 . 2958–2963 . 10.1128/AEM.02325-08. 19270147 . 2681672 . 2009ApEnM..75.2958L .