| Tom O'Brien | |
| Fullname: | Thompson Joseph O'Brien |
| Birth Date: | 11 October 1889 |
| Birth Place: | Adelong, New South Wales |
| Death Place: | Wagga Wagga |
| Originalteam: | Xavier College |
| Statsend: | 1910 |
| Years1: | 1909–10 |
| Games Goals1: | 3 (3) |
Thompson Joseph "Tom" O'Brien (11 October 1889 – 11 September 1963) was an Australian rules footballer who played with University in the Victorian Football League (VFL).