Tolibut Explained
Tolibut, also known as 3-(p-tolyl)-4-aminobutyric acid (or β-(4-methylphenyl)-GABA), is drug that was developed in Russia. It is an analogue of γ-aminobutyric acid (GABA) and is the 4-methyl analogue of phenibut, and is also an analogue of baclofen where the 4-chloro substitution has been replaced with a 4-methyl substitution. Tolibut has been described as possessing analgesic, tranquilizing, and neuroprotective properties. It is not fully clear as to whether the drug was ever approved or used medically in Russia.[1] [2] [3] [4]
See also
Notes and References
- Tyurenkov IN, Borodkina LE, Bagmetova VV . Functional aspects of neuroprotective effects of new salts and compositions of baclofen in the convulsive syndrome caused by electroshock . Bulletin of Experimental Biology and Medicine . 153 . 5 . 710–713 . September 2012 . 23113265 . 10.1007/s10517-012-1806-5 . 767044 .
- Effect of analogs of γ -aminobutyric acid on the uptake of [3H]-γ -aminobutyric acid by synaptosomes of the rat brain. Pharmaceutical Chemistry Journal . Morozov IS, Kovalev GI, Maisov NI, Kovalev GV, Raevskii KS . January 1977. 11. 1. 10–12. 10.1007/BF00779108. 27281385 .
- Dmitriev AV, Andreev NI . [The spectrum of analgesic activity of baclofen and tolibut] . ru . Farmakologiia I Toksikologiia . 50 . 1 . 24–27 . 1987 . 3556547 .
- Artem'ev II, Darinskiĭ I, Sologub MI . [A hypothesis of the possible mechanism of the action of analgesic agents at the neuronal level] . ru . Eksperimental'naia i Klinicheskaia Farmakologiia . 55 . 1 . 16–18 . 1992 . 1363942 .
