| Honorific Prefix: | Prince |
| Tokudaiji Sanetsune | |
| Native Name Lang: | ja |
| Office: | 2nd Lord Keeper of the Privy Seal |
| Term Start: | February 21, 1891 |
| Term End: | August 12, 1912 |
| Predecessor: | Sanjō Sanetomi |
| Successor: | Katsura Tarō |
| Birth Date: | 10 January 1840 |
| Death Date: | 4 June 1919 (aged 79) |
| Birth Place: | Kyoto, Japan |
| Death Place: | Tokyo, Japan |
Prince was a Japanese statesman and Lord Keeper of the Privy Seal of Japan during the Meiji era.
Tokudaiji Sanetsune was born to a branch of the Fujiwara court nobility in Kyoto. His father was Tokudaiji Kin'ito, and his brother was Saionji Kinmochi, later Prime Minister of Japan.
Joining the sonnō jōi ("Revere the Emperor, Expel the Barbarian") faction in Court against westernization and the Tokugawa shogunate, he was forced to flee Kyoto during the coup d'état by the moderate samurai of the Aizu and Satsuma domains on 18 August 1863. He returned after the Meiji Restoration and served in a number of posts in the new government. He became a Dainagon in 1869.
In 1884, he was given the title of koshaku (marquis) under the new kazoku nobility rankings, and was subsequently elevated to koshaku (prince). In 1891 he became Lord Keeper of the Privy Seal of Japan a post he held until Emperor Meiji's death. He felt very strongly that the Emperor should not involve himself in politics or in the decision-making process of government.