Togavirus 5′ plus strand cis-regulatory element explained

Togavirus 5′ plus strand cis-regulatory element
Symbol:	Toga_5_CRE
Rfam:	RF00470
Rna Type:	Cis-reg
Tax Domain:	Viruses

The Togavirus 5′ plus strand cis-regulatory element is an RNA element which is thought to be essential for both plus and minus strand RNA synthesis.^[1]

Genus Alphavirus belongs to the family Togaviridae. Alpha viruses contain secondary structural motifs in the 5′ UTR that allow them to avoid detection by IFIT1.^[2]

See also

• Rubella virus 3′ cis-acting element

Notes and References

1. Frolov I, Hardy R, Rice CM . Cis-acting RNA elements at the 5′ end of Sindbis virus genome RNA regulate minus- and plus-strand RNA synthesis . RNA . 7 . 11 . 1638–1651 . November 2001 . 11720292 . 1370205 . 10.1017/S135583820101010X .
2. Hyde JL, Gardner CL, Kimura T, White JP, Liu G, Trobaugh DW, Huang C, Tonelli M, Paessler S, Takeda K, Klimstra WB, Amarasinghe GK, Diamond MS . A viral RNA structural element alters host recognition of nonself RNA . Science . 343 . 6172 . 783–787 . February 2014 . 24482115 . 4209899 . 10.1126/science.1248465 .