Tobamovirus internal ribosome entry site (IRES) explained
Tobamovirus internal ribosome entry site (IRES) |
Symbol: | IRES_Tobamo |
Altsymbols: | Tobamo_IRES |
Rfam: | RF00225 |
Rna Type: | Cis-reg
- IRES
|
Tax Domain: | Viruses |
The Tobamovirus internal ribosome entry site (IRES) is an element that allows cap and end-independent translation of mRNA in the host cell.[1] The IRES achieves this by mediating the internal initiation of translation by recruiting a ribosomal 43S pre-initiation complex directly to the initiation codon and eliminates the requirement for the eukaryotic initiation factor, eIF4F.[2]
See also
Notes and References
- Ivanov PA, Karpova OV, Skulachev MV, Tomashevskaya OL, Rodionova NP, Atabekov JG . A tobamovirus genome that contains an internal ribosome entry site functional in vitro . Virology . 232 . 1 . 32–43 . May 1997 . 9185586 . 10.1006/viro.1997.8525 . free .
- Kolupaeva VG, Pestova TV, Hellen CU . Ribosomal binding to the internal ribosomal entry site of classical swine fever virus . RNA . 6 . 12 . 1791–1807 . December 2000 . 11142379 . 1370049 . 10.1017/S1355838200000662 .