| Tobacco River | |
| Subdivision Type1: | Country |
| Subdivision Name1: | United States |
| Pushpin Map: | USA Michigan |
| Pushpin Map Size: | 250 |
| Pushpin Map Caption: | Location within the state of Michigan |
The Tobacco River is a 12.7adj=midNaNadj=mid[1] river in the U.S. state of Michigan. Located in Gladwin and Midland counties, the river rises in Beaverton at the confluence of the river's North, Middle, and South branches in Ross Lake. The river flows southeast and empties into the Tittabawassee River at the community of Edenville. On older maps, the South branch and the lower course of the Tobacco River are identified as Samaquasebing, Assemoqua, Assymoquoasibee, etc., all derived from the Ojibwe Asemaakwe-ziibi(ing), meaning "(At) Tobacco-woman River".