| Honorific-Prefix: | Hon. |
| Tissa Karaliyedda | |
| Honorific-Suffix: | MP |
| Office: | Minister of Women's Affairs |
| President: | Mahinda Rajapaksa |
| Primeminister: | D. M. Jayaratne |
| Term Start: | 23 April 2010 |
| Term End: | 12 January 2015 |
| Successor: | Chandrani Bandara Jayasinghe |
| Constituency Mp1: | Anuradhapura |
| Parliament1: | Sri Lankan |
| Birth Place: | Anuradhapura, Sri Lanka |
| Nationality: | Sri Lankan |
| Party: | United People's Freedom Alliance |
| Occupation: | Politics |
| Alma Mater: | Nalanda College Colombo |
| Profession: | Agriculturist |
Tissa Wijeratna Karalliyadde MP (born 10 May 1952) was Sri Lanka's former Cabinet Minister of Child Development and Women's Affairs and a Member of Parliament representing the Anuradhapura District.
He is an Agriculturist by profession and was educated at Nalanda College Colombo.