Tinyatoxin Explained

Heat:Above peak
Scoville:5,300,000,000

Tinyatoxin (TTX or TTN) is an analog of the neurotoxin resiniferatoxin. It occurs naturally in Euphorbia poissonii.[1]

It is a neurotoxin that acts via full agonism of the vanilloid receptors of sensory nerves.[2] Tinyatoxin has a potential for pharmaceutical uses similar to uses of capsaicin. Tinyatoxin is about one third as strong as resiniferatoxin but is still an ultrapotent analogue of capsaicin, with a heat intensity estimate of 300 to 350 times that of capsaicin.

Notes and References

  1. http://www.botanical-dermatology-database.info/BotDermFolder/EUPH-9.html#Euphorbia%20poissonii Euphorbia poissonii
  2. Szallasi, A. . Blumberg, P.M. . amp . Characterization of vanilloid receptors in the dorsal horn of pig spinal cord . Brain Res . 547 . 335–338 . 1991 . 10.1016/0006-8993(91)90982-2 . 1884211 . 2. 25052101 .