Tinosporide Explained

Tinosporide is a chemical compound classified as a diterpenoid and a furanolactone. It was first isolated from the plant Tinospora cordifolia, from which it derives its name.^{[1] [2]} It has since been found in other plants of the genus Tinospora, such as Tinospora glabra.^{[3] [4] [5]}

Because Tinospora cordifolia has been used in traditional herbal medicine, there has been research directed at exploring the potential pharmacology of tinosporide and related compounds.^[6]

Related compounds

Other diterpenoid furanolactones with a similar structure include columbin, palmarin, and chasmanthin.

Notes and References

1. 2610955 . 1989 . Swaminathan . K. . Sinha . U. C. . Bhatt . R. K. . Sabata . B. K. . Tavale . S. S. . Structure of tinosporide, a diterpenoid furanolactone from Tinospora cordifolia Miers . Acta Crystallographica Section C . 45 . 1 . 134–136 . 10.1107/s0108270188009953 . 1989AcCrC..45..134S .
2. 10.1016/j.heliyon.2019.e02437 . The chemical constituents and diverse pharmacological importance of Tinospora cordifolia . 2019 . Sharma . Priyanka . Dwivedee . Bharat P. . Bisht . Dheeraj . Dash . Ashutosh K. . Kumar . Deepak . Heliyon . 5 . 9 . e02437 . free . 31701036 . 6827274 . 2019Heliy...502437S .
3. Web site: Isolation and Characterisation of clerodane diterpenoids from the traditional medicinal plant -Tinospora glabra (Burm. f.) Merrill.
4. Quantitative and rapid quality assessment methods for the multi-class bioactive constituents of Tinospora cordifolia using high-performance liquid and thin layer chromatography analysis with tandem mass spectrometry characterization . 10.1002/sscp.202200048 . 2022 . Girme . Aboli . Saste . Ganesh . Singh . Ruchi . Mirgal . Amit . Ingavale . Rajnita . Balasubramaniam . Arun Kumar . Ghoshal . Sautik . Ghule . Chetana . Patel . Saurabh . Verma . Mahendra Kumar . Maurya . Rakesh . Hingorani . Lal . Separation Science Plus . 5 . 8 . 378–392 . 249304214 . subscription .
5. 10.1016/j.sjbs.2021.03.063 . Cholinesterase inhibitory activity of tinosporide and 8-hydroxytinosporide isolated from Tinospora cordifolia: In vitro and in silico studies targeting management of Alzheimer's disease . 2021 . Adib . Mohiminul . Islam . Rashedul . Ahsan . Monira . Rahman . Arifur . Hossain . Mahmud . Rahman . Md Mustafizur . Alshehri . Sultan M. . Kazi . Mohsin . Mazid . Md Abdul . Saudi Journal of Biological Sciences . 28 . 7 . 3893–3900 . 34220245 . 8241625 .
6. 10.3109/13880209509065379 . Chemistry and Biological Activities of the Genera Tinospora . 1995 . Pathak . Ashish K. . Jain . Dharam C. . Sharma . Ram P. . International Journal of Pharmacognosy . 33 . 4 . 277–287 .