Timothy Bliss Explained

Tim Bliss
Birth Name:Timothy Vivian Pelham Bliss
Birth Date:1940 7, df=yes
Education:Dean Close School
Alma Mater:McGill University
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Timothy Vivian Pelham Bliss FRS (born 27 July 1940) is a British neuroscientist. He is an adjunct professor at the University of Toronto, and a group leader emeritus at the Francis Crick Institute, London.

In 2016 Professor Tim Bliss shared with Professors Graham Collingridge and Richard Morris the 2016 Brain Prize, one of the world's most coveted science prizes.[1]

Life

Born in England he was educated at Dean Close School and McGill University (BSc, 1963; PhD, 1967). In 1967 he joined the MRC National Institute for Medical Research in Mill Hill, London, where he was Head of the Division of Neurophysiology from 1988 till 2006. His work with Terje Lømo in Per Andersen's laboratory at the University of Oslo in the late 1960s established the phenomenon of long-term potentiation (LTP) as the dominant synaptic model of how the mammalian brain stores memories.

Career and research

In 1973, he and Terje Lømo published[2] the first evidence of a Hebb-like synaptic plasticity event induced by brief tetanic stimulation, known as long-term potentiation (LTP).[3] [4] [5] [6] His work has done much to provide a neural explanation for learning and memory. Studying the hippocampus – the memory centre of the brain – Tim showed that the strength of signals between neurons in the brain exhibits a long-term increase following brief but intense activation, a phenomenon known as long-term potentiation (LTP).[7]

Whilst LTP was discovered in Oslo in the lab of Per Andersen, Tim's subsequent research into the cellular properties of LTP and its relation to memory was conducted at London's National Institute for Medical Research where he worked from 1968 to 2006, becoming head of Neurosciences.[8] He is visiting professor at University College London.

Bliss is on the board of the Feldberg Foundation[9] and was trustee of Sir John Soane's Museum from 2004 to 2009.[10] From the years 2009 until 2013, Bliss worked as an adjunct professor in the South Korean university, Seoul National University.[11]

Awards and Honours

Notable Contributions

Publications and Credits
Year Title Journal
1969 Lamellar Organization of Hippocampal Excitatory Pathways[13] Acta Physiologica Scandinavica
1970 Plasticity in a Monosynaptic Cortical Pathway[14] The Journal of Physiology
1971 Unit Analysis of Hippocampal Population Spikes[15] Experimental Brain Research
1971 Long-Lasting Increases of Synaptic Influence in the Unanesthetized Hippocampus[16] The Journal of Physiology
1971 Lamellar Organization of Hippocampal Pathways[17] Experimental Brain Research
1973 Long-Lasting Potentiation of Synaptic Transmission in the Dentate Area of the Anaesthetized Rabbit Following Stimulation of the Perforant Path[18] [19] The Journal of Physiology
1979 Synaptic Plasticity in the Hippocampus[20] Trends in Neurosciences

Notes and References

  1. Web site: Biography Timothy Bliss – Grete Lundbeck European Brain Research Foundation. thebrainprize.org. 2023-03-02.
  2. 4727084. 1350458. 1973. Bliss. T. V.. Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. The Journal of Physiology. 232. 2. 331–56. Lomo. T . 10.1113/jphysiol.1973.sp010273.
  3. Dolphin. A. C.. Errington. M. L.. Bliss. T. V. P.. Long-term potentiation of the perforant path in vivo is associated with increased glutamate release. Nature. 297. 5866. 1982. 496–497. 0028-0836. 10.1038/297496a0. 6123949. 1982Natur.297..496D. 4255128.
  4. Tim V. P. Bliss, Graham L. Collingridge, Richard G. Morris, Long-term potentiation: enhancing neuroscience for 30 years, Oxford University Press, 2004,
  5. [Per Andersen]
  6. Bliss . T. V. P. . Collingridge . G. L. . 10.1038/361031a0 . A synaptic model of memory: Long-term potentiation in the hippocampus . Nature . 361 . 6407 . 31–39 . 1993 . 8421494. 1993Natur.361...31B . 4326182 .
  7. Web site: Dr Timothy Bliss FMedSci FRS. Royal Society. London. https://web.archive.org/web/20151117005208/https://royalsociety.org/people/timothy-bliss-11098/. 2015-11-17. One or more of the preceding sentences incorporates text from the royalsociety.org website where:
  8. Web site: The Committee Office, House of Commons . House of Commons – Science and Technology Committee – Written Evidence . Parliament of the United Kingdom . 2012-12-21.
  9. Web site: Board members of the Feldberg Foundation . Feldbergfoundation.org . 2012-12-21.
  10. Web site: Dr T V P Bliss, FRS Authorised Biography – Debrett's People of Today, Dr T V P Bliss, FRS Profile . www.debretts.co.uk . 13 January 2022 . https://web.archive.org/web/20120331223205/http://www.debretts.co.uk/people/biographies/browse/b/1744/Timothy%20Vivian%20Pelham+BLISS.aspx . 31 March 2012 . dead.
  11. Web site: Academy of Europe: Bliss Timothy . www.ae-info.org . 29 November 2022.
  12. Web site: Tim Bliss The Lundbeck Foundation . lundbeckfonden.com . 29 November 2022 . en.
  13. Andersen . P . Bliss . TV . Lomo . T . Olsen . LI . Skrede . KK . Lamellar organization of hippocampal excitatory pathways. . Acta Physiologica Scandinavica . May 1969 . 76 . 1 . 4A–5A . 10.1111/j.1748-1716.1969.tb04499.x . 5823402 . 28 November 2022.
  14. Bliss . TV . Lomo . T . Plasticity in a monosynaptic cortical pathway. . The Journal of Physiology . April 1970 . 207 . 2 . 61P . 5511138 . 28 November 2022.
  15. Andersen . P. . Bliss . T. V. P. . Skrede . K. K. . Unit analysis of hippocampal population spikes . Experimental Brain Research . 1 August 1971 . 13 . 2 . 208–221 . 10.1007/BF00234086 . 5123965 . 7160894 . 28 November 2022.
  16. Bliss . TV . Gardner-Medwin . AR . Long-lasting increases of synaptic influence in the unanesthetized hippocampus. . The Journal of Physiology . July 1971 . 216 . 1 . 32P–33P . 5558363 . 28 November 2022.
  17. Andersen . P . Bliss . TV . Skrede . KK . Lamellar organization of hippocampal pathways. . Experimental Brain Research . 1971 . 13 . 2 . 222–38 . 10.1007/BF00234087 . 5570425 . 12075886 . 28 November 2022.
  18. Bliss . TV . Lomo . T . Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. . The Journal of Physiology . July 1973 . 232 . 2 . 331–56 . 10.1113/jphysiol.1973.sp010273 . 4727084 . 1350458 . 2983008 .
  19. Bliss . TV . Gardner-Medwin . AR . Long-lasting potentiation of synaptic transmission in the dentate area of the unanaestetized rabbit following stimulation of the perforant path. . The Journal of Physiology . July 1973 . 232 . 2 . 357–74 . 10.1113/jphysiol.1973.sp010274 . 4727085 . 1350459 . 21559512 .
  20. Bliss . T. V. P. . Synaptic plasticity in the hippocampus . Trends in Neurosciences . 1 January 1979 . 2 . 42–45 . 10.1016/0166-2236(79)90019-5 . 53151887 . 29 November 2022.

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