Timothy J. Richmond Explained
Timothy John Richmond (born October 9, 1948, in Corvallis) is a Swiss/American molecular biologist, biochemist, and biophysicist.
He graduated in 1970 with a bachelor's degree[1] in biochemistry from Purdue University, where his teachers included Larry G. Butler (died 1997) and Michael G. Rossmann. Richmond graduated in 1975 from Yale University's department of molecular biophysics and biochemistry with a dissertation on protein-DNA interaction under the supervision of Frederic M. Richards and Thomas A. Steitz. Richmond was a postdoc at Yale University from 1975 to 1978 under the supervision of Frederic M. Richards and from 1978 to 1980 at the MRC Laboratory of Molecular Biology under the supervision of Sir Aaron Klug studying the nucleosome (which is the fundamental subunit of chromatin).[2] Richmond was from 1980 to 1987 a tenured staff scientist at the MRC Laboratory of Molecular Biology[1] and in 1987 was appointed "Professor of X-ray Crystallography of Biological Macromolecules"[2] at ETH Zurich's Institute for Molecular Biology and Biophysics.[1] At ETH Zurich he became in 2005 vice-chair of the biology department.[2]
He was the postdoctoral supervisor of Karolin Luger.[3]
Richmond was elected in 1994 a fellow of the American Association for the Advancement of Science (AAAS).[4] He was elected a member in 1995 of the European Molecular Biology Organization (EMBO),[5] in 2000 of the Academia Europaea,[1] in 2004 of the German National Academy of Sciences Leopoldina,[2] and in 2007 of the U.S. National Academy of Sciences.[6] In 2001 he was awarded an honorary doctor of science degree by Purdue University.[7] His prizes or awards include the Louis-Jeantet Prize for Medicine in 2002[8] and the Marcel Benoist Prize in 2006.[9] In 2023, Timothy J. Richmond, Daniela Rhodes and Karolin Luger were awarded the WLA Prize in Life Science or Medicine "for elucidating the structure of the nucleosome at the atomic level, providing the basis for understanding chromatin, gene regulation, and epigenetics."[10]
Selected publications
- 10.1038/311532a0. Structure of the nucleosome core particle at 7 Å resolution. 1984. Richmond. T. J.. Finch. J. T.. Rushton. B.. Rhodes. D.. Klug. A.. Nature. 311. 5986. 532–537. 6482966. 1984Natur.311..532R. 4355982. (over 1250 citations)
- 10.1016/0022-2836(84)90231-6. Solvent accessible surface area and excluded volume in proteins. 1984. Richmond. Timothy J.. Journal of Molecular Biology. 178. 1. 63–89. 6548264.
- 10.1038/376490a0. Structure of serum response factor core bound to DNA. 1995. Pellegrini. Luca. Tan. Song. Richmond. Timothy J.. Nature. 376. 6540. 490–498. 7637780. 1995Natur.376..490P. 4338634.
- 10.1038/38444. Crystal structure of the nucleosome core particle at 2.8 Å resolution. 1997. Luger. Karolin. Mäder. Armin W.. Richmond. Robin K.. Sargent. David F.. Richmond. Timothy J.. Nature. 389. 6648. 251–260. 9305837. 1997Natur.389..251L. 4328827. (over 10300 citations)
- 10.1006/jmbi.1997.1235. Characterization of nucleosome core particles containing histone proteins made in bacteria 1 1Edited by A. Klug. 1997. Luger. Karolin. Rechsteiner. Thomas J.. Flaus. Andrew J.. Waye. Mary M.Y. Richmond. Timothy J.. Journal of Molecular Biology. 272. 3. 301–311. 9325091.
- 10.1016/S0959-437X(98)80134-2. The histone tails of the nucleosome. 1998. Luger. Karolin. Richmond. Timothy J.. Current Opinion in Genetics & Development. 8. 2. 140–146. 9610403.
- 10.1016/S0959-440X(98)80007-9. DNA binding within the nucleosome core. 1998. Luger. Karolin. Richmond. Timothy J.. Current Opinion in Structural Biology. 8. 1. 33–40. 9519294.
- Book: 10.1016/S0076-6879(99)04003-3. Preparation of nucleosome core particle from recombinant histones. Chromatin. Methods in Enzymology. 1999. Luger. Karolin. Rechsteiner. Thomas J.. Richmond. Timothy J.. 304. 3–19. 10372352. 9780121822057.
- Book: 10.1385/1-59259-681-9:1. Expression and Purification of Recombinant Histones and Nucleosome Reconstitution. Chromatin Protocols. 1999. Luger. Karolin. Rechsteiner. Thomas J.. Richmond. Timothy J.. Methods in Molecular Biology. 119. 1–16. 10804500. 1-59259-681-9.
- 10.1016/S0022-2836(02)00386-8. Solvent Mediated Interactions in the Structure of the Nucleosome Core Particle at 1.9Å Resolution. 2002. Davey. Curt A.. Sargent. David F.. Luger. Karolin. Maeder. Armin W.. Richmond. Timothy J.. Journal of Molecular Biology. 319. 5. 1097–1113. 12079350. (over 1600 citations)
- 10.1038/nature01595. The structure of DNA in the nucleosome core. 2003. Richmond. Timothy J.. Davey. Curt A.. Nature. 423. 6936. 145–150. 12736678. 2003Natur.423..145R. 205209705. 2003 (over 1450 citations)
- 10.1016/S0022-2836(03)00025-1. Chromatin Fiber Folding: Requirement for the Histone H4 N-terminal Tail. 2003. Dorigo. Benedetta. Schalch. Thomas. Bystricky. Kerstin. Richmond. Timothy J.. Journal of Molecular Biology. 327. 1. 85–96. 12614610.
- 10.1126/science.1103124. Nucleosome Arrays Reveal the Two-Start Organization of the Chromatin Fiber. 2004. Dorigo. Benedetta. Schalch. Thomas. Kulangara. Alexandra. Duda. Sylwia. Schroeder. Rasmus R.. Richmond. Timothy J.. Science. 306. 5701. 1571–1573. 15567867. 2004Sci...306.1571D. 20869252.
- 10.1038/nbt1036. Baculovirus expression system for heterologous multiprotein complexes. 2004. Berger. Imre. Fitzgerald. Daniel J.. Richmond. Timothy J.. Nature Biotechnology. 22. 12. 1583–1587. 15568020. 8834637.
- 10.1038/nature03686. X-ray structure of a tetranucleosome and its implications for the chromatin fibre. 2005. Schalch. Thomas. Duda. Sylwia. Sargent. David F.. Richmond. Timothy J.. Nature. 436. 7047. 138–141. 16001076. 2005Natur.436..138S. 4387396. (over 900 citations)
References
- Web site: Timothy J. Richmond (membership number 2024). Academia Europaea.
- Web site: Deutsche Akademie der Naturforscher Leopoldina. Neue Mitglieder der Leopoldina 2004. 70.
- Web site: Timothy J. Richmond, Ph.D.. Chemistry Tree (academictree.org).
- Web site: Historic Fellows. American Association for the Advancement of Science (aaas.org).
- Web site: EMBO Member Timothy J. Richmond. EMBO.
- Web site: Member Directory: Timothy J. Richmond. National Academy of Sciences.
- Web site: Timothy Richmond. Purdue to award 15 honorary doctorates, Purdue News. April 2001.
- News: Professor Timothy J. Richmond, Winner of the 2002 Louis-Jeantet Prize for medicine. Fondation Louis-Jeantet. October 2017 .
- Web site: Laureates. Marcel Benoist Foundation.
- https://www.thewlaprize.org/PressRoom/News/2023/09/14/179.html Laureates of the 2023 WLA Prize Announced