Timiperone Explained

Timiperone, sold under the brand name Tolopelon, is a typical antipsychotic of the butyrophenone class which is marketed in Japan for the treatment of schizophrenia.^{[1] [2] [3] [4]} It is similar in chemical structure to benperidol, but has a thiourea group instead of a urea group. It acts as an antagonist for the D₂ and 5-HT_2A receptors.

Notes and References

1. Book: Index Nominum 2000: International Drug Directory . 2000 . Taylor & Francis . 978-3-88763-075-1 . 1030–.
2. Yamasaki T, Kojima H, Tanaka M, Aibara S, Hirohashi M, Kasai Y, Tsubokawa M, Watanabe K, Akashi A . 6 . Pharmacological studies on timiperone, a new neuroleptic drug Part II: General pharmacological properties . Arzneimittel-Forschung . 31 . 4 . 707–15 . 1981 . 6113834 .
3. Tanaka M, Kojima H, Akashi A . Effect of timiperone, a new antipsychotic drug, on the sleep-wakefulness cycle in cats . Japanese Journal of Pharmacology . 39 . 3 . 391–4 . November 1985 . 2869168 . 10.1254/jjp.39.391 . free .
4. Book: Miyamoto S . Timiperone . 2010 . https://doi.org/10.1007/978-3-540-68706-1_1902 . Encyclopedia of Psychopharmacology . 1323 . Stolerman IP . Berlin, Heidelberg . Springer . en . 10.1007/978-3-540-68706-1_1902 . 978-3-540-68706-1 . 2022-03-11.