Tilorone Explained

Tilorone (trade names Amixin, Lavomax and others) is the first recognized synthetic, small molecular weight compound that is an orally active interferon inducer.^[1] It is used as an antiviral drug in some countries which do not require double-blind placebo-controlled studies, including Russia. It is effective against Ebola virus in mice.^[2]

Pharmacology

Tilorone activates the production of interferon.

Notes and References

1. Stringfellow DA, Glasgow LA . Tilorone hydrochloride: an oral interferon-inducing agent . Antimicrobial Agents and Chemotherapy . 2 . 2 . 73–78 . August 1972 . 4670490 . 444270 . 10.1128/aac.2.2.73 .
2. Ekins S, Lingerfelt MA, Comer JE, Freiberg AN, Mirsalis JC, O'Loughlin K, Harutyunyan A, McFarlane C, Green CE, Madrid PB . 6 . Efficacy of Tilorone Dihydrochloride against Ebola Virus Infection . Antimicrobial Agents and Chemotherapy . 62 . 2 . February 2018 . 29133569 . 5786809 . 10.1128/AAC.01711-17 .