Tilomisole Explained

Tilomisole (WY-18,251) is an experimental drug which acts as an immunomodulator and has been studied for the treatment of some forms of cancer.[1] [2]

It can also be seen to contain the arylacetic acid moiety that is endemic to many NSAIDs, e.g. ibufenac.

Notes and References

  1. Fenichel RL, Alburn HE, Schreck PA, Bloom R, Gregory FJ . Immunomodulating and antimetastatic activity of 3-(p-chlorophenyl) thiazolo[3,2-a]benzimidazole-2-acetic acid (Wy-18,251, NSC 310633) . Journal of Immunopharmacology . 2 . 4 . 491–508 . 1980 . 10.3109/08923978009026408 . 6970786 .
  2. Dillman RO, Ryan KP, Dillman JB, Shawler DL, Maguire R . WY 18,251 (Tilomisole), an analog of levamisole: tolerability, and immune modulating effects in cancer patients . Molecular Biotherapy . 4 . 1 . 10–4 . March 1992 . 1385709 .

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