Tilapertin Explained

Iupac Name:	(4--1-piperazinyl)acetic acid
Cas Number:	1000690-85-6
Unii:	A2SV488G98
Atc Prefix:	None
Pubchem:	25063875
Chemspiderid:	32699053
Kegg:	D10672
C:	20
H:	21
F:	3
N:	2
O:	2
Smiles:	c1ccc(cc1)[C@H](c2cccc(c2)C(F)(F)F)N3CCN(CC3)CC(=O)O
Stdinchi:	1S/C20H21F3N2O2/c21-20(22,23)17-8-4-7-16(13-17)19(15-5-2-1-3-6-15)25-11-9-24(10-12-25)14-18(26)27/h1-8,13,19H,9-12,14H2,(H,26,27)/t19-/m1/s1
Stdinchikey:	MDLQJNCGZVDZFV-LJQANCHMSA-N
Legal Status:	Investigational

Tilapertin (INN), also known as AMG-747,^[1] is a investigational drug which was being evaluated as an antipsychotic.^[2]

Mechanism of action

Tilapertin appears to act via the blocking of the type 1 glycine transporter, making it a glycine re-uptake inhibitor.

History

Two studies have been made in order to determine the safety of tilapertin and its potential as an add-on to anti-psychotic therapy in people with schizophrenia. These studies were later halted due to a case of Stevens–Johnson syndrome in one of the participants.^[3]

See also

• Bitopertin

Notes and References

1. Web site: PubChem . Tilapertin . 2024-08-16 . U.S. National Library of Medicine .
2. International Nonproprietary Names for Pharmaceutical Substances (INN): Proposed INN: List 110 . . . WHO Drug Information . 27 . 4 . 2013 .
3. Dunayevich E, Buchanan RW, Chen CY, Yang J, Nilsen J, Dietrich JM, Sun H, Marder S . Efficacy and safety of the glycine transporter type-1 inhibitor AMG 747 for the treatment of negative symptoms associated with schizophrenia . Schizophrenia Research . 182 . 90–97 . April 2017 . 27789188 . 10.1016/j.schres.2016.10.027 .