Thymosin beta-4, Y-chromosomal explained

Thymosin beta-4, Y-chromosomal is a protein that in humans is encoded by the TMSB4Y gene.^{[1] [2]}

The protein consists (in humans) of 44 amino acids (msdkpgmaei ekfdksklkk tetqeknpls sketieqerq ages) MolWt 4881.^[3] __TOC__

Function

This gene lies within the male specific region of chromosome Y. Its homolog on chromosome X (thymosin beta-4) escapes X inactivation and encodes an actin sequestering protein.^[2]

Further reading

• Yu FX, Lin SC, Morrison-Bogorad M, Atkinson MA, Yin HL . Thymosin beta 10 and thymosin beta 4 are both actin monomer sequestering proteins . The Journal of Biological Chemistry . 268 . 1 . 502–9 . January 1993 . 10.1016/S0021-9258(18)54179-X . 8416954 . free .
• Li X, Zimmerman A, Copeland NG, Gilbert DJ, Jenkins NA, Yin HL . The mouse thymosin beta 4 gene: structure, promoter identification, and chromosome localization . Genomics . 32 . 3 . 388–94 . March 1996 . 8838802 . 10.1006/geno.1996.0133 .
• Toward a complete human genome sequence . Genome Research . 8 . 11 . 1097–108 . November 1998 . 9847074 . 10.1101/gr.8.11.1097 . Sanger Centre . The . Washington University Genome Sequencing Cente . The . free .
• Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, Cordum HS, Hillier L, Brown LG, Repping S, Pyntikova T, Ali J, Bieri T, Chinwalla A, Delehaunty A, Delehaunty K, Du H, Fewell G, Fulton L, Fulton R, Graves T, Hou SF, Latrielle P, Leonard S, Mardis E, Maupin R, McPherson J, Miner T, Nash W, Nguyen C, Ozersky P, Pepin K, Rock S, Rohlfing T, Scott K, Schultz B, Strong C, Tin-Wollam A, Yang SP, Waterston RH, Wilson RK, Rozen S, Page DC . The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes . Nature . 423 . 6942 . 825–37 . June 2003 . 12815422 . 10.1038/nature01722 . 2003Natur.423..825S . free .
• Torikai H, Akatsuka Y, Miyazaki M, Warren EH, Oba T, Tsujimura K, Motoyoshi K, Morishima Y, Kodera Y, Kuzushima K, Takahashi T . A novel HLA-A*3303-restricted minor histocompatibility antigen encoded by an unconventional open reading frame of human TMSB4Y gene . Journal of Immunology . 173 . 11 . 7046–54 . December 2004 . 15557202 . 10.4049/jimmunol.173.11.7046 . free .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . October 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .

Notes and References

1. Lahn BT, Page DC . Functional coherence of the human Y chromosome . Science . 278 . 5338 . 675–80 . October 1997 . 9381176 . 10.1126/science.278.5338.675 . 1997Sci...278..675L .
2. Web site: Entrez Gene: TMSB4Y thymosin, beta 4, Y-linked.
3. Web site: Thymosin beta-4, Y-chromosomal [Homo sapiens] - Protein - NCBI.