| Thulani Ncube | |
| Birth Date: | 21 September 1977 |
| Position: | defender |
| Years1: | 1998–2002 |
| Clubs1: | Highlanders F.C. |
| Years2: | 2002–2003 |
| Clubs2: | Ajax Cape Town F.C. |
| Years3: | 2003–2004 |
| Clubs3: | Cape Cod Crusaders |
| Years4: | 2005–2006 |
| Clubs4: | Highlanders F.C. |
| Nationalyears1: | 1998–2002 |
| Nationalteam1: | Zimbabwe |
| Nationalcaps1: | 25 |
| Nationalgoals1: | 0 |
Thulani Ncube (born 21 September 1977) is a retired Zimbabwean football defender.