Thrombospondin 3 Explained

Thrombospondin-3 (TSP3) is a protein that in humans is encoded by the THBS3 gene.^{[1] [2]}

The protein encoded by this gene belongs to the thrombospondin family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. TSP3 has been found to be involved in the regulation of skeletal maturation.^[3] This protein forms a pentameric molecule linked by a single disulfide bond. This gene shares a common promoter with metaxin 1. Identified as the gene on chromosome 1 responsible for mediating an associated with genetic susceptibility to SARS-CoV-2 infection.^[4]

Further reading

• O'Rourke KM, Laherty CD, Dixit VM . Thrombospondin 1 and thrombospondin 2 are expressed as both homo- and heterotrimers . J. Biol. Chem. . 267 . 35 . 24921–4 . 1993 . 10.1016/S0021-9258(19)73983-0 . 1459996 . free .
• Adolph KW, Long GL, Winfield S, etal . Structure and organization of the human thrombospondin 3 gene (THBS3) . Genomics . 27 . 2 . 329–36 . 1995 . 7558000 . 10.1006/geno.1995.1050 .
• Qabar A, Derick L, Lawler J, Dixit V . Thrombospondin 3 is a pentameric molecule held together by interchain disulfide linkage involving two cysteine residues . J. Biol. Chem. . 270 . 21 . 12725–9 . 1995 . 7759526 . 10.1074/jbc.270.21.12725 . free .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Qabar AN, Lin Z, Wolf FW, etal . Thrombospondin 3 is a developmentally regulated heparin binding protein . J. Biol. Chem. . 269 . 2 . 1262–9 . 1994 . 10.1016/S0021-9258(17)42252-6 . 8288588 . free .
• Bornstein P, Devarayalu S, Edelhoff S, Disteche CM . Isolation and characterization of the mouse thrombospondin 3 (Thbs3) gene . Genomics . 15 . 3 . 607–13 . 1993 . 8468055 . 10.1006/geno.1993.1114 .
• Winfield SL, Tayebi N, Martin BM, etal . Identification of three additional genes contiguous to the glucocerebrosidase locus on chromosome 1q21: implications for Gaucher disease . Genome Res. . 7 . 10 . 1020–6 . 1997 . 9331372 . 10.1101/gr.7.10.1020. 310674 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Adolph KW . Relative abundance of thrombospondin 2 and thrombospondin 3 mRNAs in human tissues . Biochem. Biophys. Res. Commun. . 258 . 3 . 792–6 . 1999 . 10329465 . 10.1006/bbrc.1999.0710 .
• Adolph KW, Bornstein P . The human thrombospondin 3 gene: analysis of transcription initiation and an alternatively spliced transcript . Mol. Cell Biol. Res. Commun. . 2 . 1 . 47–52 . 2000 . 10527891 . 10.1006/mcbr.1999.0148 .
• Carron JA, Hiscott P, Hagan S, etal . Cultured human retinal pigment epithelial cells differentially express thrombospondin-1, -2, -3, and -4 . Int. J. Biochem. Cell Biol. . 32 . 11–12 . 1137–42 . 2001 . 11137453 . 10.1016/S1357-2725(00)00065-0 .
• Armstrong DJ, Hiscott P, Batterbury M, Kaye S . Corneal stromal cells (keratocytes) express thrombospondins 2 and 3 in wound repair phenotype . Int. J. Biochem. Cell Biol. . 34 . 6 . 588–93 . 2002 . 11943589 . 10.1016/S1357-2725(01)00157-1 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Dalla-Torre CA, Yoshimoto M, Lee CH, etal . Effects of THBS3, SPARC and SPP1 expression on biological behavior and survival in patients with osteosarcoma . BMC Cancer . 6. 237 . 2006 . 17022822 . 10.1186/1471-2407-6-237 . 1609181 . free .

Notes and References

1. Vos HL, Devarayalu S, de Vries Y, Bornstein P . Thrombospondin 3 (Thbs3), a new member of the thrombospondin gene family . J Biol Chem . 267 . 17 . 12192–6 . Jul 1992 . 10.1016/S0021-9258(19)49823-2 . 1601886 . free .
2. Web site: Entrez Gene: THBS3 thrombospondin 3.
3. Hankenson. Kurt. Mice with a Disruption of the Thrombospondin 3 Gene Differ in Geometric and Biomechanical Properties of Bone and Have Accelerated Development of the Femoral Head. Molecular and Cellular Biology. July 2005. 25. 13. 5599–5606. 10.1128/MCB.25.13.5599-5606.2005. 15964815. 1156967.
4. Mapping the human genetic architecture of COVID-19 . Nature . July 2021 . 34237774 . 10.1038/s41586-021-03767-x . 235776838 . Niemi . Mari E. K. . Karjalainen . Juha . Liao . Rachel G. . Neale . Benjamin M. . Daly . Mark . Ganna . Andrea . Pathak . Gita A. . Andrews . Shea J. . Kanai . Masahiro . Veerapen . Kumar . Fernandez-Cadenas . Israel . Schulte . Eva C. . Striano . Pasquale . Marttila . Minttu . Minica . Camelia . Marouli . Eirini . Karim . Mohd Anisul . Wendt . Frank R. . Savage . Jeanne . Sloofman . Laura . Butler-Laporte . Guillaume . Kim . Han-Na . Kanoni . Stavroula . Okada . Yukinori . Byun . Jinyoung . Han . Younghun . Uddin . Mohammed Jashim . Smith . George Davey . Willer . Cristen J. . Buxbaum . Joseph D. . 600 . 7889 . 472–477 . 8674144 . 1 .