Threonine-phosphate decarboxylase explained

threonine-phosphate decarboxylase
Ec Number:	4.1.1.81
Go Code:	0048472

The enzyme threonine-phosphate decarboxylase catalyzes the chemical reaction

\rightleftharpoons (R)-1-aminopropan-2-yl phosphate + CO₂

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is L-threonine-O-3-phosphate carboxy-lyase [(R)-1-aminopropan-2-yl-phosphate-forming]. Other names in common use include L-threonine-O-3-phosphate decarboxylase, CobD and L-threonine-O-3-phosphate carboxy-lyase. This enzyme is part of the biosynthetic pathway to cobalamin (vitamin B₁₂) in anaerobic bacteria such as Salmonella typhimurium and Bacillus megaterium. In the next step, (R)-1-aminopropan-2-ol is attached to adenosylcobyric acid, forming adenosylcobinamide phosphate.

See also

• Cobalamin biosynthesis

References

• Cheong CG, Bauer CB, Brushaber KR, Escalante-Semerena JC, Rayment I . 2002 . Three-dimensional structure of the L-threonine-O-3-phosphate decarboxylase (CobD) enzyme from Salmonella enterica . Biochemistry . 41 . 4798 - 808 . 11939774 . 10.1021/bi012111w . 15 . 10.1.1.564.9386 .
• O'Toole GA, Escalante-Semerena JC . 1995 . Purification and characterization of the bifunctional CobU enzyme of Salmonella typhimurium LT2. Evidence for a CobU-GMP intermediate . J. Biol. Chem. . 270 . 23560 - 9 . 7559521 . 10.1074/jbc.270.40.23560 . 40 . free.
• Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC . 2002 . The biosynthesis of adenosylcobalamin (vitamin B12) . Nat. Prod. Rep. . 19 . 390 - 412 . 12195810 . 10.1039/b108967f . 4 .
• Fang . H . Kang . J . Zhang . D . Microbial production of vitamin B₁₂: a review and future perspectives. . Microbial Cell Factories . 30 January 2017 . 16 . 1 . 15 . 10.1186/s12934-017-0631-y . 28137297 . 5282855 . free .