| Genre: | Christmas |
| Screenplay: | Lloyd Gold |
| Story: | Damon Runyon |
| Director: | Robert Iscove |
| Music: | Christopher Lennertz |
| Location: | Albuquerque, NM, US |
| Cinematography: | Francis Kenny |
| Company: | Lions Gate Television |
| Network: | USA Network |
| Runtime: | 87 minutes |
Three Wise Guys is a 2005 Christmas television film.
In an update on the nativity of Jesus, a pregnant woman named Mary is helped in the desert by three mobsters. The film stars Tom Arnold, Eddie McClintock, Judd Nelson, Jodi Lyn O'Keefe, Katey Sagal, and Nick Turturro.
Filming took place in Albuquerque, New Mexico. Robert Iscove directed, with a story and screenplay by Damon Runyon and Lloyd Gold, respectively. Christopher Lennertz composed the score, and Francis Kenny was the cinematographer. At 87 minutes, the Lions Gate Television-produced film was released on the USA Network at 9p.m., December 8, 2005.