Thottopalayam thottimvirus explained

Thottopalayam thottimvirus, formerly Thottapalayam virus, (TMPV) is single-stranded, enveloped, negative-sense RNA virus species of the genus Thottimvirus in the Bunyavirales order. It is the first hantavirus to be isolated from a shrew. It was discovered in India in 1964.[1] [2]

Natural reservoir

TPMV was first isolated from an Asian house shrew (Suncus murinus) in India in 1964. It is part of a group of hantaviruses which are hosted by shrews instead of rodents.[3] These shrew-borne thottimviruses are not known to cause any known disease in humans, unlike the similar and related orthohantaviruses including Andes and Hantaan viruses, which cause lethal hemorrhagic fevers.[4]

TPMV was first isolated in Asian house shrews in Wenzhou of Zhejiang province, China.[5]

Virology

Phylogenetic analysis has shown that Thottapalayam virus, and its closely related strains, is unique and forms a distinct lineage, unrelated to other hantaviruses. The closest hantavirus to TMPV is Imjin virus which demonstrates corresponding nucleotide sequences to TPMV as does Tanganya virus.[6]

See also

External links

Notes and References

  1. Carey DE, Reuben R, Panicker KN, Shope RE, Myers RM. Thottapalayam virus: a presumptive arbovirus isolated from a shrew in India. Indian J Med Res. 1971;59:1758–60.
  2. Serge Morand, François Beaudeau, Jacques Cabaret.New Frontiers of Molecular Epidemiology of Infectious Diseases. Springer, Sep 8, 2011. pp. 198–199.
  3. Maes . Piet . Adkins . Scott . Alkhovsky . Sergey V. . Avšič-Županc . Tatjana . Ballinger . Matthew J. . Bente . Dennis A. . Beer . Martin . Bergeron . Éric . Blair . Carol D. . Briese . Thomas . Buchmeier . Michael J. . Burt . Felicity J.. Charles Calisher . Calisher . Charles H. . Charrel . Rémi N. . Choi . Il Ryong . Clegg . J. Christopher S. . de la Torre . Juan Carlos . de Lamballerie . Xavier . DeRisi . Joseph L. . Digiaro . Michele . Drebot . Mike . Ebihara . Hideki . Elbeaino . Toufic . Ergünay . Koray . Fulhorst . Charles F. . Garrison . Aura R. . Gāo . George Fú . Gonzalez . Jean-Paul J. . Groschup . Martin H. . Günther . Stephan . Haenni . Anne-Lise . Hall . Roy A. . Hewson . Roger . Hughes . Holly R. . Jain . Rakesh K. . Jonson . Miranda Gilda . Junglen . Sandra . Klempa . Boris . Klingström . Jonas . Kormelink . Richard . Lambert . Amy J. . Langevin . Stanley A. . Lukashevich . Igor S. . Marklewitz . Marco . Martelli . Giovanni P. . Mielke-Ehret . Nicole . Mirazimi . Ali . Mühlbach . Hans-Peter . Naidu . Rayapati . Nunes . Márcio Roberto Teixeira . Palacios . Gustavo . Papa . Anna . Pawęska . Janusz T. . Peters . Clarence J. . Plyusnin . Alexander . Radoshitzky . Sheli R. . Resende . Renato O. . Romanowski . Víctor . Sall . Amadou Alpha . Salvato . Maria S. . Sasaya . Takahide . Schmaljohn . Connie . Shí . Xiǎohóng . Shirako . Yukio . Simmonds . Peter . Sironi . Manuela . Song . Jin-Won . Spengler . Jessica R. . Stenglein . Mark D. . Tesh . Robert B. . Turina . Massimo . Wèi . Tàiyún . Whitfield . Anna E. . Yeh . Shyi-Dong . Zerbini . F. Murilo . Zhang . Yong-Zhen . Zhou . Xueping . Kuhn . Jens H. . Taxonomy of the order Bunyavirales: second update 2018 . Archives of Virology . 20 January 2019 . 164 . 3 . 927–941 . 10.1007/s00705-018-04127-3 . 30663021 . 6581445 .
  4. Jonsson . C. B. . Figueiredo . L. T. M. . Vapalahti . O. . A Global Perspective on Hantavirus Ecology, Epidemiology, and Disease . Clinical Microbiology Reviews . 7 April 2010 . 23 . 2 . 412–441 . 10.1128/CMR.00062-09 . 20375360 . 2863364 .
  5. Wen-Ping Guo, Xian-Dan Lin, Wen Wang, Xiao-He Zhang, Yi Chen, Jian-Hai Cao, Qing-Xiang Ni, Wang-Cang Li, Ming-Hui Li, Alexander Plyusnin, Yong-Zhen Zhang. A new subtype of Thottapalayam virus carried by the Asian house shrew (Suncus murinus) in China. Infection, genetics and evolution: journal of molecular epidemiology and evolutionary genetics in infectious diseases (Impact Factor: 3.22). 07/2011; 11(8):1862–7.
  6. Wen-Ping Guo, Xian-Dan Lin, Wen Wang, Xiao-He Zhang, Yi Chen, Jian-Hai Cao, Qing-Xiang Ni, Wang-Cang Li, Ming-Hui Li, Alexander Plyusnin, Yong-Zhen Zhang. A new subtype of Thottapalayam virus carried by the Asian house shrew (Suncus murinus) in China. Infection, genetics and evolution: journal of molecular epidemiology and evolutionary genetics in infectious diseases (Impact Factor: 3.22). 07/2011; 11(8):1862–7.

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