Thorpe reaction explained

The Thorpe reaction is a chemical reaction described as a self-condensation of aliphatic nitriles catalyzed by base to form enamines.^{[1] [2] [3]} The reaction was discovered by Jocelyn Field Thorpe.

Thorpe–Ziegler reaction

The Thorpe–Ziegler reaction (named after Jocelyn Field Thorpe and Karl Ziegler), or Ziegler method, is the intramolecular modification with a dinitrile as a reactant and a cyclic ketone as the final reaction product after acidic hydrolysis. The reaction is conceptually related to the Dieckmann condensation.^[4]

External links

• Thorpe-Ziegler reaction: 4-Phosphorinanone, 1-phenyl- Organic Syntheses, Coll. Vol. 6, p. 932 (1988); Vol. 53, p. 98 (1973) Link

Notes and References

1. Baron. Harold. Remfry. Frederick George Percy. Thorpe. Jocelyn Field. Jocelyn Field Thorpe. CLXXV.—The formation and reactions of imino-compounds. Part I. Condensation of ethyl cyanoacetate with its sodium derivative. Journal of the Chemical Society, Transactions . 85. 1904. 1726–1761. 0368-1645. 10.1039/CT9048501726.
2. Ziegler . K. . Eberle . H. . Ohlinger . H. . 1933 . Über vielgliedrige Ringsysteme. I. Die präparativ ergiebige Synthese der Polymethylenketone mit mehr als 6 Ringgliedern . Justus Liebig's Annalen der Chemie . German . 504 . 1 . 94–130 . 10.1002/jlac.19335040109 . 0075-4617.
3. Book: Schaefer. John P.. Organic Reactions. Bloomfield. Jordan J.. The Dieckmann Condensation (Including the Thorpe-Ziegler Condensation). 2011. 1–203. 10.1002/0471264180.or015.01. 978-0471264187.
4. Book: Schaefer. John P.. Organic Reactions. Bloomfield. Jordan J.. The Dieckmann Condensation (Including the Thorpe-Ziegler Condensation). 2011. 1–203. 10.1002/0471264180.or015.01. 978-0471264187.