| Thompson Run | |
| Name Other: | Tributary to Beaver River |
| Map Size: | 300 |
| Pushpin Map: | USA Pennsylvania#USA |
| Pushpin Map Size: | 300 |
| Pushpin Map Caption: | Location of Thompson Run mouth |
| Subdivision Type1: | Country |
| Subdivision Name1: | United States of America |
| Subdivision Type2: | State |
| Subdivision Name2: | Pennsylvania |
| Subdivision Type3: | County |
| Subdivision Name3: | Beaver |
| Length: | 1.32miles[1] |
| Discharge1 Avg: | 1.63cuft/s at mouth with Beaver River[2] |
| Source1: | divide between Thompson Run and Brush Run |
| Source1 Location: | about 2 miles east of Homewood, Pennsylvania |
| Source1 Coordinates: | 40.8061°N -80.2889°W[3] |
| Source1 Elevation: | 1140feet[4] |
| Mouth: | Beaver River |
| Mouth Location: | Homewood, Pennsylvania |
| Mouth Coordinates: | 40.8103°N -80.3178°W[5] |
| Mouth Elevation: | 735feet[6] |
| Progression: | Beaver River → Ohio River → Mississippi River → Gulf of Mexico |
| River System: | Beaver River |
| Basin Size: | [7] |
| Tributaries Left: | unnamed tributaries |
| Tributaries Right: | unnamed tributaries |
Thompson Run is a tributary of the Beaver River in western Pennsylvania. The stream rises in north-central Beaver County and flows west entering the Beaver River at Homewood, Pennsylvania. The watershed is roughly 12.5% agricultural, 54% forested and the rest is other uses.[8]