Tomas Lindahl Explained

Tomas Lindahl
Honorific Suffix:FRS FMedSci
Birth Name:Tomas Robert Lindahl
Birth Date:1938 1, df=yes
Birth Place:Stockholm, Sweden
Nationality:Swedish, naturalised British
(dual nationality)
Thesis Title:On the structure and stability of nucleic acids in solution
Thesis Year:1967
Thesis Url:http://libris.kb.se/bib/1308970
Known For:Clarification of cellular resistance to carcinogens

Tomas Robert Lindahl FRS[1] FMedSci (born 28 January 1938) is a Swedish-British scientist specialising in cancer research.[2] In 2015, he was awarded the Nobel Prize in Chemistry jointly with American chemist Paul L. Modrich and Turkish chemist Aziz Sancar for mechanistic studies of DNA repair.[3] [4] [5]

Education

Lindahl was born in Kungsholmen, Stockholm, Sweden to Folke Robert Lindahl and Ethel Hulda Hultberg.[6] He received a PhD degree in 1967,[7] and an MD degree qualification in 1970, from the Karolinska Institutet in Stockholm.

Career and research

After obtaining his research doctorate, Lindahl did postdoctoral research at Princeton University and Rockefeller University.[8] He was professor of medical chemistry at the University of Gothenburg 1978–82. After moving to the United Kingdom he joined the Imperial Cancer Research Fund (now Cancer Research UK) as a researcher in 1981. From 1986 to 2005 he was the first Director of Cancer Research UK's Clare Hall Laboratories in Hertfordshire, since 2015 part of the Francis Crick Institute.[9] He continued to research there until 2009. He has contributed to many papers on DNA repair and the genetics of cancer.[10] [11] [12] [13] [14] [15] [16] [17]

Awards and honours

Lindahl was elected an EMBO Member in 1974 and Fellow of the Royal Society (FRS) in 1988,[18] his certificate of election reads: Lindahl received the Royal Society's Royal Medal in 2007 "making fundamental contributions to our understanding of DNA repair. His achievements stand out for their great originality, breadth and lasting influence."[19] He is a member of the Norwegian Academy of Science and Letters.[20] He was awarded the Copley Medal in 2010. He was elected a founding Fellow of the Academy of Medical Sciences (FMedSci) in 1998. In 2018, he was elected a foreign associate of the National Academy of Sciences.

He shared the Nobel Prize in Chemistry in 2015. The Swedish Academy noted that "The Nobel Prize in Chemistry 2015 was awarded jointly to Tomas Lindahl, Paul Modrich and Aziz Sancar 'for mechanistic studies of DNA repair'."[21]

External links

Notes and References

  1. Web site: Lindahl, Tomas Robert: EC/1988/20 . The Royal Society . 2019-07-10 . dead . https://web.archive.org/web/20190710061326/https://collections.royalsociety.org/DServe.exe?dsqIni=Dserve.ini&dsqApp=Archive&dsqDb=Catalog&dsqCmd=show.tcl&dsqSearch=(RefNo

    %27EC/1988/20%27)

    . London.
  2. Web site: https://web.archive.org/web/20151201194741/http://crick.ac.uk/research/a-z-researchers/emeritus-scientists/tomas-lindahl/. 2015-12-01. Emeritus Scientist – Tomas Lindahl. The Crick.
  3. News: Nobel Prize in Chemistry Awarded to Tomas Lindahl, Paul Modrich and Aziz Sancar for DNA Studies. The New York Times. 2015-10-07. 2015-10-07. 0362-4331. William J.. Broad.
  4. News: Staff . THE NOBEL PRIZE IN CHEMISTRY 2015 – DNA repair – providing chemical stability for life . 7 October 2015 . . 2015-10-07 .
  5. Cressey. Daniel. DNA repair sleuths win chemistry Nobel: Tomas Lindahl, Paul Modrich and Aziz Sancar share 2015 prize. Nature. 526. 7573. 307–8. 2015. 1476-4687. 10.1038/nature.2015.18515. 26469021. free.
  6. Sweden, Indexed Birth Records, 1860–1941
  7. Book: Lindahl, Tomas. On the structure and stability of nucleic acids in solution. 1967. Stockholm.
  8. Web site: Cancer Research UK Grants & Research – Tomas Lindahl. 2008-11-10.
  9. http://scienceblog.cancerresearchuk.org/2015/10/07/4-ways-that-tomas-lindahls-nobel-prize-for-chemistry-revolutionised-cancer-research/ "4 ways that Tomas Lindahl’s Nobel Prize for Chemistry revolutionised cancer research"
  10. Gerken . T. is. Girard . C. A.. Tung . Y. -C. L.. Webby . C. J.. Saudek . V.. Hewitson . K. S.. Yeo . G. S. H.. McDonough . M. A.. Cunliffe . S.. McNeill. 10.1126/science.1151710 . L. A.. Galvanovskis . J.. Rorsman . P.. Patrik Rorsman. Robins . P.. Prieur . X.. Coll . A. P.. Ma . M.. Jovanovic . Z.. Farooqi . I. S. . Sadaf Farooqi. Sedgwick . B.. Barroso . I.. Lindahl . T.. Tomas Lindahl. Ponting . C. P.. Chris Ponting. Ashcroft . F. M.. Frances Ashcroft. O'Rahilly . S.. Stephen O'Rahilly. Schofield . C. J.. Christopher J. Schofield. The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase. Science. 318. 5855. 1469–1472. 2008. 17991826. 2668859 . 2007Sci...318.1469G.
  11. 10.1038/362709a0. Instability and decay of the primary structure of DNA. Nature. 362. 6422. 709–15. 1993. Lindahl . T. . 8469282. 1993Natur.362..709L. 4283694.
  12. 10.1126/science.1056154. Human DNA Repair Genes. Science. 291. 5507. 1284–9. 2001. Wood . R. D. . 11181991. 2001Sci...291.1284W.
  13. 10.1038/356356a0. 1549180. 1992Natur.356..356S. Role of poly(ADP-ribose) formation in DNA repair. Nature. 356. 6367. 356–8. 1992. Satoh . M. S. . Lindahl . T. . 4364270.
  14. 12226667. 2002. Trewick. S. C.. Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage. Nature. 419. 6903. 174–8. Henshaw. T. F.. Hausinger. R. P.. Lindahl. T. Sedgwick. B. 10.1038/nature00908. 2002Natur.419..174T. 4324333.
  15. 15568983. 2004. Barnes. D. E.. Repair and genetic consequences of endogenous DNA base damage in mammalian cells. Annual Review of Genetics. 38. 445–76. Lindahl. T. 10.1146/annurev.genet.38.072902.092448.
  16. 18045533. 2007. Yang. Y. G.. Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease. Cell. 131. 5. 873–86. Lindahl. T. Barnes. D. E.. 10.1016/j.cell.2007.10.017. 2332259. free.
  17. 16845398. 2006. Crow. Y. J.. Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus. Nature Genetics. 38. 8. 917–20. Hayward. B. E.. Parmar. R. Robins. P. Leitch. A. Ali. M. Black. D. N.. Van Bokhoven. H. Brunner. H. G.. Hamel. B. C.. Corry. P. C.. Cowan. F. M.. Frints. S. G.. Klepper. J. Livingston. J. H.. Lynch. S. A.. Massey. R. F.. Meritet. J. F.. Michaud. J. L.. Ponsot. G. Voit. T. Lebon. P. Bonthron. D. T.. Jackson. A. P.. Barnes. D. E.. Lindahl. T. 10.1038/ng1845. 9069106.
  18. Web site: https://web.archive.org/web/20150922225130/https://royalsociety.org/people/tomas-lindahl-11820/. 2015-09-22. Anon. 1988. Dr Tomas Lindahl FMedSci FRS. Royal Society. London. royalsociety.org. One or more of the preceding sentences incorporates text from the royalsociety.org website where:
  19. Web site: Royal recent winners. 2008-11-10.
  20. Web site: Gruppe 6: Cellebiologi og molekylærbiologi. Norwegian Academy of Science and Letters. no. 2010-10-07.
  21. Web site: The Nobel Prize in Chemistry 2015. nobelprize.org.

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