| Thomas County Central High School | |
| Streetaddress: | 4686 US Hwy 84 Bypass |
| City: | Thomasville |
| State: | Georgia |
| Zipcode: | 31792 |
| Country: | United States |
| District: | Thomas County School District |
| Superintendent: | Lisa Williams |
| Principal: | James Thompson |
| Grades: | 9–12 |
| Enrollment: | 1,448 (2022–23)[1] |
| Ratio: | 14.56 |
| Teaching Staff: | 95.60 |
| Nickname: | Yellow Jackets |
| Colors: | Navy blue and Vegas gold |
| Conference: | GHSA Region 2-AAAAA |
| Rivals: | Cairo High School Thomasville High School |
| Newspaper: | The Swarm |
| Yearbook: | VESPA |
| Established: | 1958 |
| Type: | Public high school |
Thomas County Central High School is a high school in Thomasville, Georgia, United States.