| Thomas Clark Trimble III | |
| Office: | Senior Judge of the United States District Court for the Eastern District of Arkansas |
| Term Start: | January 14, 1957 |
| Term End: | July 6, 1965 |
| Office1: | Chief Judge of the United States District Court for the Eastern District of Arkansas |
| Term Start1: | 1948 |
| Term End1: | 1957 |
| Predecessor1: | Office established |
| Successor1: | J. Smith Henley |
| Office2: | Judge of the United States District Court for the Eastern District of Arkansas |
| Term Start2: | June 18, 1937 |
| Term End2: | January 14, 1957 |
| Appointer2: | Franklin D. Roosevelt |
| Predecessor2: | John Ellis Martineau |
| Successor2: | J. Smith Henley |
| Birth Name: | Thomas Clark Trimble III |
| Birth Date: | 27 August 1878 |
| Birth Place: | Lonoke, Arkansas |
| Death Place: | Little Rock, Arkansas |
| Education: | University of Arkansas School of Law (LL.B.) |
Thomas Clark Trimble III (August 27, 1878 – July 6, 1965) was a United States district judge of the United States District Court for the Eastern District of Arkansas.
Born in Lonoke, Arkansas, Trimble received a Bachelor of Laws in 1902 from the University of Arkansas School of Law at Fayetteville. He was in private practice in Lonoke from 1902 to 1937.
On June 17, 1937, Trimble was nominated by President Franklin D. Roosevelt to a seat on the United States District Court for the Eastern District of Arkansas vacated by Judge John Ellis Martineau. Trimble was confirmed by the United States Senate, and received his commission on June 18, 1937. He served as Chief Judge from 1948 to 1957 and assumed senior status on January 14, 1957. Trimble served in that capacity until his death on July 6, 1965, in Little Rock, Arkansas.
Trimble married Elsie Jane Walls. The couple had a daughter, Elsijane Trimble Roy, who was appointed in 1977 by President Jimmy Carter to a joint seat on the United States District Court for the Eastern District of Arkansas and the United States District Court for the Western District of Arkansas.