| Thomas Alexander Murphree | |
| Office: | Judge of the United States District Court for the Northern District of Alabama |
| Term Start: | May 31, 1938 |
| Term End: | September 5, 1945 |
| Appointer: | Franklin D. Roosevelt |
| Predecessor: | Seat established by 52 Stat. 120 |
| Successor: | Seybourn Harris Lynne |
| Birth Name: | Thomas Alexander Murphree |
| Birth Date: | 1 December 1883 |
| Birth Place: | Blount County, Alabama |
| Education: | University of Alabama (B.S.) University of Alabama School of Law (LL.B.) |
Thomas Alexander Murphree (December 1, 1883 – September 5, 1945) was a United States district judge of the United States District Court for the Northern District of Alabama.
Born in Blount County, Alabama, Murphree received a Bachelor of Science degree from the University of Alabama in 1910 and a Bachelor of Laws from the University of Alabama School of Law in 1911. He was in private practice in Birmingham, Alabama from 1911 to 1938.
On May 12, 1938, Murphree was nominated by President Franklin D. Roosevelt to a new seat on the United States District Court for the Northern District of Alabama created by 52 Stat. 120. He was confirmed by the United States Senate on May 17, 1938, and received his commission on May 31, 1938. Murphree served in that capacity until his death on September 5, 1945.