Thomas A. Rando Explained

Thomas A. Rando
Birth Date:1957
Birth Place:Brooklyn, NY
Workplaces:Stanford University School of Medicine
Discipline:Neurology, stem cell biology, biology of aging, regenerative medicine, tissue engineering
Alma Mater:Harvard College
Harvard Medical School

Thomas A. Rando is an American stem cell biologist and neurologist, best known for his research on basic mechanisms of stem cell biology and the biology of aging. He is the Director of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research and a professor of Neurology and Molecular, Cell and Developmental Biology at the University of California, Los Angeles.[1] Prior to joining the UCLA faculty, he served as Professor of Neurology and Neurological Sciences at Stanford University School of Medicine, where he was also founding director of the Glenn Center for the Biology of Aging.[2] His additional roles while at Stanford included co-founder and deputy director of the Stanford Center on Longevity, founding director of Stanford's Muscular Dystrophy Association Clinic, and Chief of Neurology at the VA Palo Alto Health Care System.[3] [4] [5]

Biography

Rando was born in Brooklyn, New York,[6] and grew up in Maine.[7] He earned a bachelor's degree from Harvard College in biochemistry in 1979, and an MD from Harvard Medical School and PhD in cell and developmental biology from Harvard University in 1987.[5] [7] [8] He interned at Massachusetts General Hospital and completed his residency in neurology at the University of California, San Francisco.[9] He joined Stanford's Department of Molecular Pharmacology as a research fellow in 1991, and joined Stanford's medical school faculty in 1995.[8] He relocated to Los Angeles to join the UCLA faculty in 2021.[10] Rando is also a founder of Fountain Therapeutics.[11]

Research

Rando’s research on stem cells has addressed how stem cells in tissues throughout the body maintain their potency to participate in tissue homeostasis and tissue repair throughout the life of an organism.[12] [13] [14] Through these studies, his laboratory has explored the basic mechanisms by which stem cells maintain a dormant, or “quiescent” state, when not engage in generation of new tissue.[15] [16] [17] They have demonstrated how the depth of stem cell quiescence influences the potency of those cells to participate in tissue repair and regeneration.[18] These findings have led to advances in studies of stem cell therapeutics in the broader field of regenerative medicine.[19]

In 2005, Rando’s laboratory was the first to use the technique of heterochronic parabiosis to explore the effects of the systemic circulation on stem cell function.[20] [21] [22] Rando’s group has pioneered studies of the epigenetics of stem cell aging, exploring the role of “epigenetic rejuvenation” as an explanation for the paradigm-shifting findings of heterochronic parabiosis.[23] [24] These studies have revealed how exercise itself can lead to rejuvenation of aged stem cells.[25] Their studies focus on physiologic, pharmacologic, genetic, and dietary interventions to reverse cellular aging and to produce therapies for aging-related diseases.[26] [27] [28]

Rando's research interests also include muscular dystrophies, tissue engineering, and regenerative rehabilitation.[14] [29] [30] [31] [32]

Honors

External links

Notes and References

  1. Web site: Thomas A. Rando, MD, PhD . 2022-09-28 . Regenerative Medicine at the McGowan Institute . en-US.
  2. News: Stanford Lands $5M Grant . 28 July 2021 . San Francisco Business Times . 22 February 2011.
  3. Web site: Thomas Rando named director of UCLA Broad Stem Cell Research Center . 2022-09-28 . UCLA . en-US.
  4. Web site: People at the Stanford Center on Longevity. 2020-06-30. longevity.stanford.edu.
  5. Web site: Profile . stanford.edu . 28 July 2021.
  6. News: Rejuvenecer nuestras células puede hacerlas más proclives al cáncer . 28 July 2021 . El Pais . 14 May 2018.
  7. News: Rando to head geriatric center at Palo Alto VA . 28 July 2021 . Stanford News . 24 May 2000.
  8. News: Promotions announced for two School of Medicine faculty members . 28 July 2021 . Stanford News . 4 December 2002.
  9. Web site: Dr. Thomas Rando Elected to National Academy of Medicine . mirm-pitt.net . 18 November 2016 . 28 July 2021.
  10. Web site: Thomas Rando named director of UCLA Broad Stem Cell Research Center . 2022-09-28 . UCLA . en-US.
  11. Web site: Fountain Therapeutics Closes $6 Million Series A-1 Financing . mirm-pitt.net . 3 June 2020 . 28 July 2021.
  12. News: Stem cells, ageing and the quest for immortality . 30 July 2021 . Nature . 28 June 2006.
  13. Stem cells and healthy aging . 30 July 2021 . Science . 4 December 2015. 10.1126/science.aab3388 . Goodell . Margaret A. . Rando . Thomas A. . 350 . 6265 . 1199–1204 . 26785478 . 2015Sci...350.1199G . 29472696 .
  14. News: Stem cell therapy for muscular dystrophies . 30 July 2021 . The Journal of Clinical Investigation . 18 September 2020.
  15. Bjornson. Christopher R. R.. Cheung. Tom H.. Liu. Ling. Tripathi. Pinky V.. Steeper. Katherine M.. Rando. Thomas A.. 2012. Notch Signaling Is Necessary to Maintain Quiescence in Adult Muscle Stem Cells. Stem Cells. en. 30. 2. 232–242. 10.1002/stem.773. 1549-4918. 3384696. 22045613.
  16. Cheung. Tom H.. Quach. Navaline L.. Charville. Gregory W.. Liu. Ling. Park. Lidia. Edalati. Abdolhossein. Yoo. Bryan. Hoang. Phuong. Rando. Thomas A.. February 2012. Maintenance of muscle stem-cell quiescence by microRNA-489. Nature. en. 482. 7386. 524–528. 10.1038/nature10834. 0028-0836. 3292200. 22358842. 2012Natur.482..524C.
  17. News: Molecular regulation of stem cell quiescence . 30 July 2021 . Nature Reviews Molecular Cell Biology . 23 May 2013.
  18. Rodgers. Joseph T.. King. Katherine Y.. Brett. Jamie O.. Cromie. Melinda J.. Charville. Gregory W.. Maguire. Katie K.. Brunson. Christopher. Mastey. Namrata. Liu. Ling. Tsai. Chang-Ru. Goodell. Margaret A.. 2014-06-19. mTORC1 controls the adaptive transition of quiescent stem cells from G0 to GAlert. Nature. 510. 7505. 393–396. 10.1038/nature13255. 0028-0836. 4065227. 24870234. 2014Natur.510..393R.
  19. Quarta. Marco. Cromie. Melinda. Chacon. Robert. Blonigan. Justin. Garcia. Victor. Akimenko. Igor. Hamer. Mark. Paine. Patrick. Stok. Merel. Shrager. Joseph B.. Rando. Thomas A.. 20 June 2017. Bioengineered constructs combined with exercise enhance stem cell-mediated treatment of volumetric muscle loss. Nature Communications. 8. 15613. 10.1038/ncomms15613. 2041-1723. 5481841. 28631758. 2017NatCo...815613Q.
  20. Toledano. Hila. 2014-04-06. Faculty Opinions recommendation of Rejuvenation of aged progenitor cells by exposure to a young systemic environment.. 10.3410/f.1024195.793493221 . free .
  21. Brack. Andrew S.. Conboy. Michael J.. Roy. Sudeep. Lee. Mark. Kuo. Calvin J.. Keller. Charles. Rando. Thomas A.. 2007-08-10. Increased Wnt Signaling During Aging Alters Muscle Stem Cell Fate and Increases Fibrosis. Science. en. 317. 5839. 807–810. 10.1126/science.1144090. 0036-8075. 17690295. 2007Sci...317..807B. 6767424.
  22. News: Healthy aging – it's still all about diet and exercise. For now. . 30 July 2021 . Longevity Technology . 31 August 2020.
  23. Rando. Thomas A.. Chang. Howard Y.. 2012-01-20. Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock. Cell. English. 148. 1. 46–57. 10.1016/j.cell.2012.01.003. 0092-8674. 22265401. 3336960.
  24. Sarkar. Tapash Jay. Quarta. Marco. Mukherjee. Shravani. Colville. Alex. Paine. Patrick. Doan. Linda. Tran. Christopher M.. Chu. Constance R.. Horvath. Steve. Qi. Lei S.. Bhutani. Nidhi. 2020-03-24. Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells. Nature Communications. en. 11. 1. 1545. 10.1038/s41467-020-15174-3. 32210226. 7093390. 2020NatCo..11.1545S. 2041-1723. free.
  25. Brett. Jamie O.. Arjona. Marina. Ikeda. Mika. Quarta. Marco. de Morrée. Antoine. Egner. Ingrid M.. Perandini. Luiz A.. Ishak. Heather D.. Goshayeshi. Armon. Benjamin. Daniel I.. Both. Pieter. April 2020. Exercise rejuvenates quiescent skeletal muscle stem cells in old mice through restoration of Cyclin D1. Nature Metabolism. en. 2. 4. 307–317. 10.1038/s42255-020-0190-0. 32601609. 2522-5812. 7323974.
  26. News: Turning Back the Clock on Aging Cells . 30 July 2021 . The New York Times . 24 March 2020.
  27. News: Old human cells rejuvenated with stem cell technology . 30 July 2021 . Science Daily . 24 March 2020.
  28. News: Asynchronous, contagious and digital aging . 30 July 2021 . Nature Aging . 14 January 2021.
  29. Maguire. Katie K.. Lim. Leland. Speedy. Sedona. Rando. Thomas A.. May 2013. Assessment of disease activity in muscular dystrophies by noninvasive imaging. The Journal of Clinical Investigation. 123. 5. 2298–2305. 10.1172/JCI68458. 1558-8238. 3638910. 23619364.
  30. News: Firefly protein lights up degenerating muscles, aiding muscular-dystrophy research . 30 July 2021 . Science Daily . 24 April 2013.
  31. News: An artificial niche preserves the quiescence of muscle stem cells and enhances their therapeutic efficacy . 30 July 2021 . Nature Biotechnology . 30 May 2016.
  32. News: Regenerative Rehabilitation: Applied Biophysics Meets Stem Cell Therapeutics . 30 July 2021 . Cell Stem Cell . 1 March 2018.
  33. News: Three at Stanford win NIH awards, funding . 30 July 2021 . San Francisco Business Times . 29 September 2005.
  34. News: Board Member in the News: Thomas Rando elected to the American Academy of Arts and Sciences . 30 July 2021 . AFAR . 6 May 2020.
  35. News: Stanford scientists awarded grants for innovative research . 30 July 2021 . Stanford Medicine . 30 September 2013.
  36. Web site: 2015 AAAS Fellows Recognized for Contributions to Advancing Science. 2020-06-30. American Association for the Advancement of Science. en.
  37. Web site: Class of 2016. 2020-06-30. National Academy of Medicine. en-US.
  38. Web site: New Members. 2020-06-30. American Academy of Arts & Sciences. en.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Thomas A. Rando".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2024, A B Cryer, All Rights Reserved. Cookie policy.