Thiopropazate Explained

Thiopropazate (Artalan, Dartal, Dartalan, Dartan) is a typical antipsychotic of the phenothiazine class.^[1] It is a prodrug to perphenazine.

Thiopropazate is manufactured by Searle (US, UK) & Boehringer Mannheim (Germany)^[2] Thiopropazate is sold by Chembase, AAA Chemistry, ZINC, AKos Consulting & Solutions, Boc Sciences, ChemFrog, and ChemMol^[3]

Synthesis

The alkylation of 2-chloro-10-(3-chloropropyl)phenothiazine [2765-59-5] (1) with Piperazine (2) gives N-Desmethylprochlorperazine [40323-85-1] (3). Further alkylation with 2-Bromoethyl acetate [927-68-4] (4) gives Thiopropazate (5).

See also

• Typical antipsychotic
• Phenothiazine

Notes and References

1. Book: Buckingham J . Dictionary of organic compounds . Chapman & Hall . London . 1996 . 5148 . 0-412-54090-8 .
2. Pharmaceutical Manufacturing Encyclopedia p. 3209
3. Web site: Thiopropazate . PubChem . United States Library of Medicine .