Thiocoraline Explained

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Thiocoraline is a microbial natural product of the depsipeptide class. Thiocoraline was isolated from the mycelium cake of a marine actinomycete strain L-13-ACM2-092.^[1] In vitro, thiocoraline causes an arrest in G1 phase of the cell cycle and decreases the rate of S phase progression towards G2/M phase.^[2] Thiocoraline is likely to be a DNA replication inhibitor. Thiocoraline is produced on a nonribosomal peptide synthetase (NRPS) assembly line.^[3]

Notes and References

1. Romero F, Espliego F, Pérez Baz J, García de Quesada T, Grávalos D, de la Calle F, Fernández-Puentes JL . Thiocoraline, a new depsipeptide with antitumor activity produced by a marine Micromonospora. I. Taxonomy, fermentation, isolation, and biological activities . The Journal of Antibiotics . 50 . 9 . 734–7 . September 1997 . 9360617 . 10.7164/antibiotics.50.734. free .
2. Erba E, Bergamaschi D, Ronzoni S, Faretta M, Taverna S, Bonfanti M, Catapano CV, Faircloth G, Jimeno J, D'Incalci M . Mode of action of thiocoraline, a natural marine compound with anti-tumour activity . British Journal of Cancer . 80 . 7 . 971–80 . June 1999 . 10362104 . 2363046 . 10.1038/sj.bjc.6690451 .
3. Lombó F, Velasco A, Castro A, de la Calle F, Braña AF, Sánchez-Puelles JM, Méndez C, Salas JA . Deciphering the biosynthesis pathway of the antitumor thiocoraline from a marine actinomycete and its expression in two Streptomyces species . ChemBioChem . 7 . 2 . 366–76 . February 2006 . 16408310 . 10.1002/cbic.200500325 . 28760297 .