Thiazovivin Explained
Thiazovivin is a drug which acts as a potent and selective inhibitor of the enzyme Rho kinase. It is used alongside a cocktail of other growth factors and modulators in cell culture techniques for the generation of induced pluripotent stem cells, which can then be used for a wide variety of applications.[1] [2] [3] [4]
See also
Notes and References
- Lin T, Ambasudhan R, Yuan X, Li W, Hilcove S, Abujarour R, Lin X, Hahm HS, Hao E, Hayek A, Ding S . 6 . A chemical platform for improved induction of human iPSCs . Nature Methods . 6 . 11 . 805–8 . November 2009 . 19838168 . 10.1038/nmeth.1393 . 3724527 .
- Donai K, Inagaki A, So KH, Kuroda K, Sone H, Kobayashi M, Nishimori K, Fukuda T . 6 . Low-molecular-weight inhibitors of cell differentiation enable efficient growth of mouse iPS cells under feeder-free conditions . Cytotechnology . 67 . 2 . 191–7 . March 2015 . 24682663 . 10.1007/s10616-013-9686-8 . 4329295 .
- Mohseni R, Shoae-Hassani A, Verdi J . Reprogramming of endometrial adult stromal cells in the presence of a ROCK inhibitor, thiazovivin, could obtain more efficient iPSCs . Cell Biology International . 39 . 5 . 515–8 . May 2015 . 25490878 . 10.1002/cbin.10411 . 24813753 .
- Cheng L, Lei Q, Yin C, Wang HY, Jin K, Xiang M . Generation of Urine Cell-Derived Non-integrative Human iPSCs and iNSCs: A Step-by-Step Optimized Protocol . Frontiers in Molecular Neuroscience . 2017 . 10 . 348 . 29163026 . 10.3389/fnmol.2017.00348 . 5670152 . free .
