| Consort: | no |
| Theodora Komnene | |
| Birth Date: | 15 January 1096 |
| Birth Place: | Constantinople (modern-day Istanbul, Turkey) |
| Death Date: | unknown |
| Religion: | Orthodox |
| Spouse: | Constantine Kourtikes Constantine Angelos |
| Issue: | John Doukas Alexios Komnenos Angelos Andronikos Doukas Angelos Isaac Angelos Maria Angelina Eudokia Angelina Zoe Angelina |
| Father: | Alexios I Komnenos |
| Mother: | Irene Doukaina |
| House: | Komnenos |
Theodora Komnene (Greek, Modern (1453-);: {{lang|grc|Θεοδώρα Κομνηνή; born 15 January 1096) was a Byzantine noblewoman, being the fourth daughter of Emperor Alexios I Komnenos and Irene Doukaina. She married Constantine Angelos, by whom she had seven children. Byzantine emperors Alexios III Angelos and Isaac II Angelos were her grandsons, thereby making her an ancestor of the Angelos dynasty.
Theodora was born in Constantinople 15 January 1096, the fourth of the five daughters, and seventh child overall, of Emperor Alexios I Komnenos and Irene Doukaina. In she married the nobleman Constantine Kourtikes, but her husband died by 1118—Theodora is mentioned as a widow at that time—and the marriage remained childless. In, certainly after the death of Alexios I, she married a second time, to Constantine Angelos, a minor noble from Philadelphia. He was exceedingly beautiful, but Empress Irene apparently disapproved of it, and it seems to have soured her relations with Theodora, who is listed last and with the least favourable provisions in the typikon that Irene granted to the Kecharitomene Monastery. Theodora herself is mentioned for the last time in October 1136, and it is unknown when she died. Her husband went on to hold a series of not very successful military commands under Manuel I Komnenos . He is last attested in 1166.
From her second marriage to Constantine Angelos, Theodora had seven children. Through her sons, Theodora was the progenitor of the Angelos dynasty, which produced three Byzantine emperors, as well as the Komnenodoukas family, which founded the state of Epirus–Thessalonica.