Thelazia callipaeda explained

Thelazia callipaeda is a parasitic nematode, and the most common cause of thelaziasis (or eyeworm infestation) in humans, dogs and cats.[1] It was first discovered in the eyes of a dog in China in 1910.[2] By 2000, over 250 human cases had been reported in the medical literature.[3]

Morphology

The adult Thelazia callipaeda worm typically measures 5 to 20 mm in length and 250 to 800 μm in diameter. The males tend to be smaller than the females in size. In distinguishing this species from other worms, they have a distinct buccal capsule and a cuticle with spaced transverse striations giving it a ridged appearance. Adult females could also be identified by the position of their vulva which is anterior to the oesophagus-intestinal junction. The males can be distinguished by their possession of five pairs of postcloacal papillae.[4]

Hosts

In addition to humans, cats and dogs,[1] definitive hosts of T. callipaeda include the wolf (Canis lupus), raccoon dog (Nyctereutes procyonoides), red fox (Vulpes fulva), and European rabbit (Oryctolagus cuniculus). This species has been found in China, France, Germany, India, Indonesia, Italy, Japan, Korea, the Netherlands, Russia, Switzerland, Taiwan, Croatia and Thailand.[5] In 2021, the parasite was additionally found in the United States.[6]

Two intermediate hosts have been identified so far: Phortica variegata (Diptera: Drosophilidae) in Europe and Phortica okadai in China,[7] which feed on tears of humans and carnivores.[8] Some data suggests that only the males of A. (P.) variegata carry Thelazia callipaeda larvae, making Thelazia the only parasite species known to be spread exclusively by a male vector.[9] [10]

Life cycle

The eggs of Thelazia callipaeda develop into first stage larvae (L1), in utero while the female is in the tissues in and around the eye of the definitive host.[11] The female deposits these larvae, which are still enclosed in the egg membranes, in the tears (lacrymal secretions) of the host. When a tear-feeding fly (intermediate host) feeds, it ingests the T. callipaeda larvae. Once inside the fly, the L1 larvae "hatch" from the egg membrane and penetrate the gut wall. They remain in the hemocoel (the fly's circulatory system) for 2 days, and then invade either the fat body or testes of the flies. In these tissues, the larvae develop into third stage larvae (L3). The L3 migrates to the head of the fly, and is released in or near the eye of a new host mammal when the fly feeds again. Once in the eye, eyelid, tear glands, or tear ducts of the mammalian host, the L3 larvae develop through the L4 larval stage and into adults in about 1 month. The seasonal timing of L1 and L4 larvae in the lacrymal (tear) secretions of naturally infested dogs in Italy was found to coincide with the activity of the fly vectors.[12]

Symptoms, diagnosis and treatment

Symptoms of T. callipaeda infestation include conjunctivitis, excessive watering (lacrimation), visual impairment, and ulcers or scarring of the cornea. In some cases, the only symptom is the worm obscuring the host's vision as a "floater".[13]

Diagnosis is made by finding the adult worms in the eye or surrounding tissues. Human cases are treated by simply removing the worms. In canines, topical imidacloprid with moxidectin,[14] or milbemycin oxime (Interceptor)[15] have been recommended.

In canines, prevention against canine thelaziosis by monthly administrations of a combination of milbemycin oxime and afoxolaner has been found effective.[16]

Notes and References

  1. do Vale. Beatriz. Lopes. Ana Patrícia. da Conceição Fontes. Maria. Silvestre. Mário. Cardoso. Luís. Coelho. Ana Cláudia. Systematic review on infection and disease caused by Thelazia callipaeda in Europe: 2001–2020. Parasite. 27. 2020. 52. 1776-1042. 10.1051/parasite/2020048. 32996882. 7526429. free.
  2. Railliet . A. . A. . Henry . 1910 . vanc . Nouvelles observations sur les Thélazies, Nématodes parasites de l'oeil . . 68 . 213–216, 783–785.
  3. Koyama Y, Ohira A, Kono T, Yoneyama T, Shiwaku K . Five cases of thelaziasis . The British Journal of Ophthalmology . 84 . 4 . 439c–439 . April 2000 . 10777285 . 1723424 . 10.1136/bjo.84.4.439c .
  4. Otranto . Domenico . Eberhard . Mark . Zoonotic helminths affecting the human eye . Parasites & Vectors . 23 March 2011 . 4 . 41 . 1756-3305 . 10.1186/1756-3305-4-41 . 21429191 . 3071329 . free .
  5. Otranto D, Dutto M . Human thelaziasis, Europe . Emerging Infectious Diseases . 14 . 4 . 647–9 . April 2008 . 18394285 . 2570937 . 10.3201/eid1404.071205 . Free full text .
  6. Schwartz A, Lejeune M, Verocai GG, Young R, Schwartz PH . Autochthonous Thelazia callipaeda Infection in Dog, New York, USA, 2020 . Emerging Infectious Diseases . 27 . 7 . 1923-1926 . May 12, 2021 . 10.3201/eid2707.210019 . Free full text. 8237891 .
  7. Otranto D, Lia RP, Cantacessi C, Testini G, Troccoli A, Shen JL, Wang ZX . Nematode biology and larval development of Thelazia callipaeda (Spirurida, Thelaziidae) in the drosophilid intermediate host in Europe and China . Parasitology . 131 . Pt 6 . 847–55 . December 2005 . 16336738 . 10.1017/S0031182005008395 . 32500537 .
  8. Otranto D, Brianti E, Cantacessi C, Lia RP, Máca J . The zoophilic fruitfly Phortica variegata: morphology, ecology and biological niche . Medical and Veterinary Entomology . 20 . 4 . 358–64 . December 2006 . 17199746 . 10.1111/j.1365-2915.2006.00643.x . 29371796 .
  9. Otranto D, Cantacessi C, Testini G, Lia RP . Phortica variegata as an intermediate host of Thelazia callipaeda under natural conditions: evidence for pathogen transmission by a male arthropod vector . International Journal for Parasitology . 36 . 10–11 . 1167–73 . September 2006 . 16842795 . 10.1016/j.ijpara.2006.06.006 .
  10. Otranto D, Stevens JR, Cantacessi C, Gasser RB . Parasite transmission by insects: a female affair? . Trends in Parasitology . 24 . 3 . 116–20 . March 2008 . 18258484 . 10.1016/j.pt.2007.12.005 .
  11. Book: Anderson, Roy C. . 2000 . T. callipaeda Railliet and Henry, 1910 . https://books.google.com/books?id=lEERbfsvP1EC&pg=PA405 . Nematode parasites of vertebrates: their development and transmission . . . 405 . 978-0-85199-421-5 . 42080206.
  12. Otranto D, Lia RP, Buono V, Traversa D, Giangaspero A . Biology of Thelazia callipaeda (Spirurida, Thelaziidae) eyeworms in naturally infected definitive hosts . Parasitology . 129 . Pt 5 . 627–33 . November 2004 . 15552407 . 10.1017/S0031182004006018 . 23696681 .
  13. Zakir R, Zhong-Xia Z, Chioddini P, Canning CR . Intraocular infestation with the worm, Thelazia callipaeda . The British Journal of Ophthalmology . 83 . 10 . 1194–5 . October 1999 . 10636646 . 1722833 . 10.1136/bjo.83.10.1194a . free .
  14. Bianciardi P, Otranto D . Treatment of dog thelaziosis caused by Thelazia callipaeda (Spirurida, Thelaziidae) using a topical formulation of imidacloprid 10% and moxidectin 2.5% . Veterinary Parasitology . 129 . 1–2 . 89–93 . April 2005 . 15817208 . 10.1016/j.vetpar.2004.12.020 .
  15. Ferroglio E, Rossi L, Tomio E, Schenker R, Bianciardi P . Therapeutic and prophylactic efficacy of milbemycin oxime (Interceptor) against Thelazia callipaeda in naturally exposed dogs . Veterinary Parasitology . 154 . 3–4 . 351–3 . July 2008 . 18456409 . 10.1016/j.vetpar.2008.03.011 .
  16. Lebon. Wilfried. Guillot. Jacques. Álvarez. Maria-Jesús. Antonio Bazaga. José. Cortes-Dubly. Marie-Laure. Dumont. Pascal. Eberhardt. Marianne. Gómez. Héctor. Pennant. Olivier. Siméon. Noémie. Beugnet. Frederic. Halos. Lénaïg. Prevention of canine ocular thelaziosis (Thelazia callipaeda) with a combination of milbemycin oxime and afoxolaner (Nexgard Spectra®) in endemic areas in France and Spain. Parasite. 26. 2019. 1. 1776-1042. 10.1051/parasite/2019001. 30644355. 6333103.

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