| Official Name: | Tha Khantho |
| Native Name: | ท่าคันโท |
| Native Name Lang: | th |
| Settlement Type: | District |
| Subdivision Type: | Country |
| Subdivision Name: | Thailand |
| Subdivision Type1: | Province |
| Subdivision Name1: | Kalasin |
| Subdivision Type2: | Seat |
| Subdivision Type3: | Subdistrict |
| Subdivision Type4: | Muban |
| Established Title: | District established |
| Population Total: | 37,293 |
| Population As Of: | 2005 |
| Blank Name Sec1: | Postal code |
| Blank Info Sec1: | 46190 |
| Blank Name Sec2: | Geocode |
| Blank Info Sec2: | 4611 |
| Timezone: | ICT |
| Utc Offset: | +7 |
| Coordinates: | 16.94°N 103.2444°W |
Tha Khantho (Thai: ท่าคันโท, in Thai pronounced as /tʰâː kʰān.tʰōː/) is the northwesternmost district (amphoe) of Kalasin province, northeastern Thailand.
Neighboring districts are (from the south clockwise): Nong Kung Si of Kalasin Province; Kranuan of Khon Kaen province; Kumphawapi, Si That, and Wang Sam Mo of Udon Thani province.
The minor district (king amphoe) Tha Khantho was established on 1 October 1962, when the two tambons Tha Khantho and Khok Khruea were split off from Sahatsakhan district. It was upgraded to a full district on 2 October 1965. Khok Khruea was later reassigned to Nong Kung Si District.
The district is divided into six sub-districts (tambons), which are further subdivided into 59 villages (mubans). Tha Khantho is a township (thesaban tambon) which covers tambon Tha Khantho and parts of Na Tan. There are a further six tambon administrative organizations (TAO).
| No. | Name | Thai name | Villages | Pop. | ||
|---|---|---|---|---|---|---|
| 1. | Tha Khantho | ท่าคันโท | 9 | 5,770 | ||
| 2. | Kung Kao | กุงเก่า | 11 | 6,608 | ||
| 3. | Yang Um | ยางอู้ม | 6 | 4,412 | ||
| 4. | Kut Chik | กุดจิก | 11 | 5,457 | ||
| 5. | Na Tan | นาตาล | 13 | 10,433 | ||
| 6. | Dong Sombun | ดงสมบูรณ์ | 9 | 4,613 |