| State: | TX |
| Type: | SH |
| Route: | 159 |
| Map Custom: | yes |
| Map Notes: | SH 159 highlighted in red |
| Length Mi: | 57.73 |
| Length Round: | 2 |
| Established: | 1930 |
| Direction A: | West |
| Direction B: | East |
| Terminus A: | Bus. SH 71 at La Grange |
| Junction: | |
| Terminus B: | at Hempstead |
| Previous Type: | SH |
| Previous Route: | 158 |
| Next Type: | SH |
| Next Route: | 160 |
State Highway 159 (SH 159) is a Texas state highway that runs from La Grange to Fayetteville in Fayette County, through Industry and Bellville in Austin County, and ends at Hempstead in Waller County. The route was designated on March 19, 1930 from SH 73 east to Hempstead as a renumbering of SH 73A. On December 8, 1932, it was extended west to northeast of La Grange, replacing part of SH 73, which had been rerouted further south earlier.[1] On September 26, 1939, SH 159 was extended to La Grange, replacing part of SH 237.
SH 159 begins at Bus. SH 71 in downtown La Grange and heads northeast. The highway intersects with SH 71 on the outskirts of La Grange.